Professional background

Professor Lunn is professor of clinical neurology, consultant neurologist and is also clinical lead in neuroimmunology at Queen Square. He sees patients with all types of neurological disease, but his practice is increasingly focused on peripheral nerve disease, especially inflammatory peripheral nerve diseases and diseases of the nervous system associated with haematological problems.

His particular clinical and research interests are the neuropathies, of all sorts, but particularly those cause by the immune system and malignancies. However any disorders of the neuromuscular system are always of interest as is general neurology. His outpatient practice as part of the peripheral nerve service in the MRC Centre for Neuromuscular Disease at the National Hospital for Neurology and Neurosurgery covers all inflammatory neuropathies, including clinics run jointly with haematology and with multidisciplinary support from neurophysiologists and nurse specialists.

With Dr Shirley D'Sa at UCLH, he runs the only specialised POEMS service in the UK. A limited number of appointments are open to NHS e-Referral Service (formally Choose and Book referrals) for patients with peripheral nerve disease.

He runs the neuroimmunology and CSF Laboratory (NICL) which performs specialist CSF, serum, plasma and other body fluid tests for a range of neurological diseases. Antibodies, biomarkers and cellular indicators of disease are all part of the NICL repertoire, which retains its ISO15189 UKAS accreditation.


Research interests

Professor Lunn's specialist clinical and research interests are in the inflammatory neuropathies, particularly Guillain-Barré syndrome, CIDP and paraproteinaemic neuropathies.




1: Cregg R, Laguda B, Werdehausen R, Cox JJ, Linley JE, Ramirez JD, Bodi I,
Markiewicz M, Howell KJ, Chen YC, Agnew K, Houlden H, Lunn MP, Bennett DL, Wood
JN, Kinali M. Novel Mutations Mapping to the Fourth Sodium Channel Domain of
Nav1.7 Result in Variable Clinical Manifestations of Primary Erythromelalgia.
Neuromolecular Med. 2013 Jan 6. [Epub ahead of print] PubMed PMID: 23292638.

2: Vivekananda U, Lunn MP, Brew S, Miller DH. Cervical transverse myelitis like
presentation of cranial dural arteriovenous fistula. Clin Neurol Neurosurg. 2012
Nov 22. doi:pii: S0303-8467(12)00553-7. 10.1016/j.clineuro.2012.10.019. [Epub
ahead of print] PubMed PMID: 23182605.

3: Saifee TA, Schwingenschuh P, Reilly MM, Lunn MP, Katschnig P, Kassavetis P,
Pareés I, Manji H, Bhatia K, Rothwell JC, Edwards MJ. Tremor in inflammatory
neuropathies. J Neurol Neurosurg Psychiatry. 2012 Sep 5. [Epub ahead of print]
PubMed PMID: 22952325.

4: Pitceathly RD, Murphy SM, Cottenie E, Chalasani A, Sweeney MG, Woodward C,
Mudanohwo EE, Hargreaves I, Heales S, Land J, Holton JL, Houlden H, Blake J,
Champion M, Flinter F, Robb SA, Page R, Rose M, Palace J, Crowe C, Longman C,
Lunn MP, Rahman S, Reilly MM, Hanna MG. Genetic dysfunction of MT-ATP6 causes
axonal Charcot-Marie-Tooth disease. Neurology. 2012 Sep 11;79(11):1145-54. doi:
10.1212/WNL.0b013e3182698d8d. Epub 2012 Aug 29. PubMed PMID: 22933740; PubMed
Central PMCID: PMC3525307.

5: Mattsson N, Zegers I, Andreasson U, Bjerke M, Blankenstein MA, Bowser R,
Carrillo MC, Gobom J, Heath T, Jenkins R, Jeromin A, Kaplow J, Kidd D, Laterza
OF, Lockhart A, Lunn MP, Martone RL, Mills K, Pannee J, Ratcliffe M, Shaw LM,
Simon AJ, Soares H, Teunissen CE, Verbeek MM, Umek RM, Vanderstichele H,
Zetterberg H, Blennow K, Portelius E. Reference measurement procedures for
Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches
with focus on amyloid ?42. Biomark Med. 2012 Aug;6(4):409-17. doi:
10.2217/bmm.12.39. Review. PubMed PMID: 22917143.

6: Zetterberg H, Lunn MP, Herukka SK. Clinical use of cerebrospinal fluid
biomarkers in Alzheimer's disease. Biomark Med. 2012 Aug;6(4):371-6. doi:
10.2217/bmm.12.47. PubMed PMID: 22917139.

7: Goebel A, Lecky B, Smith LJ, Lunn MP. Pain intensity and distribution in
chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. 2012
Aug;46(2):294-5. doi: 10.1002/mus.23355. PubMed PMID: 22806382.

8: Hughes RA, Lunn MP. Neuromuscular disease: IVIg for neuromuscular
disease-effective but expensive. Nat Rev Neurol. 2012 May 22;8(6):303-5. doi:
10.1038/nrneurol.2012.92. PubMed PMID: 22614848.

9: Lunn MP, Nobile-Orazio E. Immunotherapy for IgM anti-myelin-associated
glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database
Syst Rev. 2012 May 16;5:CD002827. doi: 10.1002/14651858.CD002827.pub3. Review.
PubMed PMID: 22592686.

10: Murphy SM, Laura M, Fawcett K, Pandraud A, Liu YT, Davidson GL, Rossor AM,
Polke JM, Castleman V, Manji H, Lunn MP, Bull K, Ramdharry G, Davis M, Blake JC,
Houlden H, Reilly MM. Charcot-Marie-Tooth disease: frequency of genetic subtypes
and guidelines for genetic testing. J Neurol Neurosurg Psychiatry. 2012
Jul;83(7):706-10. doi: 10.1136/jnnp-2012-302451. Epub 2012 May 10. PubMed PMID:

11: Vanhoutte EK, Faber CG, Merkies IS; PeriNomS Study Group. MRC sum-score in
the ICU: good reliability does not necessarily reflect "true reliability". Muscle
Nerve. 2012 May;45(5):767-8; author reply 768-9. doi: 10.1002/mus.23344. PubMed
PMID: 22499112.

12: Arthur-Farraj PJ, Murphy SM, Laura M, Lunn MP, Manji H, Blake J, Ramdharry G,
Fox Z, Reilly MM. Hand weakness in Charcot-Marie-Tooth disease 1X. Neuromuscul
Disord. 2012 Jul;22(7):622-6. doi: 10.1016/j.nmd.2012.02.008. Epub 2012 Mar 28.
PubMed PMID: 22464564.

13: Vanhoutte EK, Faber CG, van Nes SI, Jacobs BC, van Doorn PA, van Koningsveld
R, Cornblath DR, van der Kooi AJ, Cats EA, van den Berg LH, Notermans NC, van der
Pol WL, Hermans MC, van der Beek NA, Gorson KC, Eurelings M, Engelsman J, Boot H,
Meijer RJ, Lauria G, Tennant A, Merkies IS; PeriNomS Study Group. Modifying the
Medical Research Council grading system through Rasch analyses. Brain. 2012
May;135(Pt 5):1639-49. doi: 10.1093/brain/awr318. Epub 2011 Dec 20. PubMed PMID:
22189568; PubMed Central PMCID: PMC3338921.

14: Hutton EJ, Carty L, Laurá M, Houlden H, Lunn MP, Brandner S, Mirsky R, Jessen
K, Reilly MM. c-Jun expression in human neuropathies: a pilot study. J Peripher
Nerv Syst. 2011 Dec;16(4):295-303. doi: 10.1111/j.1529-8027.2011.00360.x. PubMed
PMID: 22176144.

15: Trip SA, Saifee T, Honan W, Chandrashekar H, Lunn MP, Yousry T, Koltzenburg
M, Reilly MM. Chronic immune sensory polyradiculopathy with cranial and
peripheral nerve involvement. J Neurol. 2012 Jun;259(6):1238-40. doi:
10.1007/s00415-011-6326-0. Epub 2011 Nov 29. PubMed PMID: 22124665.

16: Morrow JM, D'Sa S, Page RA, Hilali MA, Lunn MP, Reilly MM. Rituximab
responsive multiple radiculopathies and cranial nerve palsies in association with
chronic lymphocytic leukaemia. J Neurol. 2012 Mar;259(3):571-3. doi:
10.1007/s00415-011-6217-4. Epub 2011 Sep 2. PubMed PMID: 21887515.

17: Ambrose HE, Granerod J, Clewley JP, Davies NW, Keir G, Cunningham R,
Zuckerman M, Mutton KJ, Ward KN, Ijaz S, Crowcroft NS, Brown DW; UK Aetiology of
Encephalitis Study Group. Diagnostic strategy used to establish etiologies of
encephalitis in a prospective cohort of patients in England. J Clin Microbiol.
2011 Oct;49(10):3576-83. doi: 10.1128/JCM.00862-11. Epub 2011 Aug 24. PubMed
PMID: 21865429; PubMed Central PMCID: PMC3187347.

18: Hamid JS, Meaney C, Crowcroft NS, Granerod J, Beyene J; UK Health Protection
Agency Aetiology of Encephalitis Study Group. Potential risk factors associated
with human encephalitis: application of canonical correlation analysis. BMC Med
Res Methodol. 2011 Aug 22;11:120. doi: 10.1186/1471-2288-11-120. PubMed PMID:
21859458; PubMed Central PMCID: PMC3189172.

19: Smith LJ, Murphy SM, Holmes P, Reilly MM, Reiniger L, Thom M, Lunn MP. A
painful right leg. BMJ. 2011 Mar 16;342:d1009. doi: 10.1136/bmj.d1009. PubMed
PMID: 21411806.

20: Singh JA, Wells GA, Christensen R, Tanjong Ghogomu E, Maxwell L, Macdonald
JK, Filippini G, Skoetz N, Francis D, Lopes LC, Guyatt GH, Schmitt J, La Mantia
L, Weberschock T, Roos JF, Siebert H, Hershan S, Lunn MP, Tugwell P, Buchbinder
R. Adverse effects of biologics: a network meta-analysis and Cochrane overview.
Cochrane Database Syst Rev. 2011 Feb 16;(2):CD008794. doi:
10.1002/14651858.CD008794.pub2. Review. PubMed PMID: 21328309.

21: Saifee TA, Reilly MM, Ako E, Rugg-Gunn F, Brandner S, Lunn MP, Leary SM.
Sarcoidosis presenting as acute inflammatory demyelinating
polyradiculoneuropathy. Muscle Nerve. 2011 Feb;43(2):296-8. doi:
10.1002/mus.21890. PubMed PMID: 21254101.

22: Murphy SM, Khan U, Alifrangis C, Hazell S, Hrouda D, Blake J, Ball J, Gabriel
C, Markarian P, Rees J, Karim A, Seckl MJ, Lunn MP, Reilly MM. Anti
Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated
paraneoplastic syndromes. J Neurol Neurosurg Psychiatry. 2012 Feb;83(2):232-3.
doi: 10.1136/jnnp.2010.223271. Epub 2011 Jan 4. PubMed PMID: 21205983.

23: Saifee TA, Elliott KJ, Rabin N, Yong KL, D'Sa S, Brandner S, Lunn MP, Blake
J, Reilly MM. Bortezomib-induced inflammatory neuropathy. J Peripher Nerv Syst.
2010 Dec;15(4):366-8. doi: 10.1111/j.1529-8027.2010.00287.x. Erratum in: J
Peripher Nerv Syst. 2011 Mar;16(1):74. PubMed PMID: 21199108.

24: Russo M, Laurá M, Polke JM, Davis MB, Blake J, Brandner S, Hughes RA, Houlden
H, Bennett DL, Lunn MP, Reilly MM. Variable phenotypes are associated with PMP22
missense mutations. Neuromuscul Disord. 2011 Feb;21(2):106-14. doi:
10.1016/j.nmd.2010.11.011. Epub 2010 Dec 30. PubMed PMID: 21194947.

25: Hamid JS, Meaney C, Crowcroft NS, Granerod J, Beyene J; UK Etiology of
Encephalitis Study Group. Cluster analysis for identifying sub-groups and
selecting potential discriminatory variables in human encephalitis. BMC Infect
Dis. 2010 Dec 31;10:364. doi: 10.1186/1471-2334-10-364. PubMed PMID: 21192831;
PubMed Central PMCID: PMC3022837.

26: El-Tawil S, Al Musa T, Valli H, Lunn MP, El-Tawil T, Weber M. Quinine for
muscle cramps. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD005044. doi:
10.1002/14651858.CD005044.pub2. Review. PubMed PMID: 21154358.

27: Joint Task Force of the EFNS and the PNS. European Federation of Neurological
Societies/Peripheral Nerve Society Guideline on management of paraproteinemic
demyelinating neuropathies. Report of a Joint Task Force of the European
Federation of Neurological Societies and the Peripheral Nerve Society--first
revision. J Peripher Nerv Syst. 2010 Sep;15(3):185-95. doi:
10.1111/j.1529-8027.2010.00278.x. PubMed PMID: 21040140.

28: Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, Cunningham
R, Zuckerman M, Mutton KJ, Solomon T, Ward KN, Lunn MP, Irani SR, Vincent A,
Brown DW, Crowcroft NS; UK Health Protection Agency (HPA) Aetiology of
Encephalitis Study Group. Causes of encephalitis and differences in their
clinical presentations in England: a multicentre, population-based prospective
study. Lancet Infect Dis. 2010 Dec;10(12):835-44. doi:
10.1016/S1473-3099(10)70222-X. Epub 2010 Oct 15. Erratum in: Lancet Infect Dis.
2011 Feb;11(2):79. PubMed PMID: 20952256.

29: Khaleeli Z, Healy DG, Briddon A, Lunn MP, Reilly MM, Land J, Giovannoni G.
[Copper deficiency as a treatable cause of poor balance]. Praxis (Bern 1994).
2010 Sep 22;99(19):1153-6. doi: 10.1024/1661-8157/a000258. German. PubMed PMID:

30: Sadnicka A, Reilly MM, Mummery C, Brandner S, Hirsch N, Lunn MP. Rituximab in
the treatment of three coexistent neurological autoimmune diseases: chronic
inflammatory demyelinating polyradiculoneuropathy, Morvan syndrome and myasthenia
gravis. J Neurol Neurosurg Psychiatry. 2011 Feb;82(2):230-2. doi:
10.1136/jnnp.2009.174888. Epub 2010 May 12. PubMed PMID: 20462915.

31: Hutton EJ, Lunn MP. Treatment in inflammatory neuropathies. Expert Rev Clin
Immunol. 2010 Mar;6(2):231-45. PubMed PMID: 20402386.

32: Granerod J, Cunningham R, Zuckerman M, Mutton K, Davies NW, Walsh AL, Ward
KN, Hilton DA, Ambrose HE, Clewley JP, Morgan D, Lunn MP, Solomon T, Brown DW,
Crowcroft NS. Causality in acute encephalitis: defining aetiologies. Epidemiol
Infect. 2010 Jun;138(6):783-800. doi: 10.1017/S0950268810000725. Epub 2010 Apr
14. Review. PubMed PMID: 20388231.

33: Khaleeli Z, Healy DG, Briddon A, Lunn MP, Reilly MM, Land J, Giovannoni G.
Copper deficiency as a treatable cause of poor balance. BMJ. 2010 Apr
12;340:c508. doi: 10.1136/bmj.c508. PubMed PMID: 20385722.

34: van Nes SI, Vanhoutte EK, Faber CG, Garssen M, van Doorn PA, Merkies IS;
PeriNomS Study Group. Improving fatigue assessment in immune-mediated
neuropathies: the modified Rasch-built fatigue severity scale. J Peripher Nerv
Syst. 2009 Dec;14(4):268-78. doi: 10.1111/j.1529-8027.2009.00238.x. PubMed PMID:

35: Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy or
chronic pain. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007115. doi:
10.1002/14651858.CD007115.pub2. Review. PubMed PMID: 19821395.

36: Lunn MP, Willison HJ. Diagnosis and treatment in inflammatory neuropathies.
Postgrad Med J. 2009 Aug;85(1006):437-46. doi: 10.1136/jnnp.2008.158303. PubMed
PMID: 19633010.

37: Michell AW, Laura M, Blake J, Lunn MP, Cox A, Gibbons VS, Davis MB, Wood NW,
Manji H, Houlden H, Murray NM, Reilly MM. GJB1 gene mutations in suspected
inflammatory demyelinating neuropathies not responding to treatment. J Neurol
Neurosurg Psychiatry. 2009 Jun;80(6):699-700. doi: 10.1136/jnnp.2008.150557.
PubMed PMID: 19448103.

38: Lunn MP, Willison HJ. Diagnosis and treatment in inflammatory neuropathies. J
Neurol Neurosurg Psychiatry. 2009 Mar;80(3):249-58. doi:
10.1136/jnnp.2008.158303. Review. Erratum in: J Neurol Neurosurg Psychiatry. 2009
May;80(5):584. Dosage error in article text. PubMed PMID: 19228670.

39: Lunn MP, Clarke C, Aldeen T. Acute paraplegia in a patient with AIDS and a
normal CSF examination. J Hosp Med. 2008 May;3(3):279-80. doi: 10.1002/jhm.303.
PubMed PMID: 18571806.

40: Lunn MP, Léger JM, Merkies IS, Van den Bergh P, van Schaik IN; Inflammatory
Neuropathy Consortium; ENMC. 151st ENMC international workshop: Inflammatory
Neuropathy Consortium 13th-15th April 2007, Schiphol, The Netherlands.
Neuromuscul Disord. 2008 Jan;18(1):85-9. Epub 2007 Sep 14. PubMed PMID: 17869518.

41: Lunn MP. Pinpointing peripheral neuropathies. Practitioner. 2007
May;251(1694):67-8, 71-4, 76-7 passim. Review. PubMed PMID: 17564137.

42: Allen D, Lunn MP, Niermeijer J, Nobile-Orazio E. Treatment for IgG and IgA
paraproteinaemic neuropathy. Cochrane Database Syst Rev. 2007 Jan
24;(1):CD005376. Review. PubMed PMID: 17253554.

43: Descamps MJ, Barrett L, Groves M, Yung L, Birch R, Murray NM, Linch DC, Lunn
MP, Reilly MM. Primary sciatic nerve lymphoma: a case report and review of the
literature. J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1087-9. Review. PubMed
PMID: 16914759; PubMed Central PMCID: PMC2077757.

44: Lunn MP, Nobile-Orazio E. Immunotherapy for IgM anti-myelin-associated
glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database
Syst Rev. 2006 Apr 19;(2):CD002827. Review. Update in: Cochrane Database Syst
Rev. 2012;5:CD002827. PubMed PMID: 16625561.

45: Lunn MP, Nobile-Orazio E. Immunotherapy for IgM anti-Myelin-Associated
Glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database
Syst Rev. 2003;(1):CD002827. Review. Update in: Cochrane Database Syst Rev.
2006;(2):CD002827. PubMed PMID: 12535440.

46: Gong Y, Tagawa Y, Lunn MP, Laroy W, Heffer-Lauc M, Li CY, Griffin JW, Schnaar
RL, Sheikh KA. Localization of major gangliosides in the PNS: implications for
immune neuropathies. Brain. 2002 Nov;125(Pt 11):2491-506. PubMed PMID: 12390975.

47: Hadden RD, Bensa S, Lunn MP, Hughes RA. Immunoadsorption inferior to plasma
exchange in a patient with chronic inflammatory demyelinating
polyradiculoneuropathy. J Neurol Neurosurg Psychiatry. 2002 May;72(5):644-6.
PubMed PMID: 11971054; PubMed Central PMCID: PMC1737854.

48: Lunn MP, Crawford TO, Hughes RA, Griffin JW, Sheikh KA.
Anti-myelin-associated glycoprotein antibodies alter neurofilament spacing.
Brain. 2002 Apr;125(Pt 4):904-11. PubMed PMID: 11912122.

49: Lunn MP, Johnson LA, Fromholt SE, Itonori S, Huang J, Vyas AA, Hildreth JE,
Griffin JW, Schnaar RL, Sheikh KA. High-affinity anti-ganglioside IgG antibodies
raised in complex ganglioside knockout mice: reexamination of GD1a
immunolocalization. J Neurochem. 2000 Jul;75(1):404-12. PubMed PMID: 10854286.

50: Lunn MP, Muir P, Brown LJ, MacMahon EM, Gregson NA, Hughes RA.
Cytomegalovirus is not associated with IgM anti-myelin-associated
glycoprotein/sulphate-3-glucuronyl paragloboside antibody-associated neuropathy.
Ann Neurol. 1999 Aug;46(2):267-70. PubMed PMID: 10443896.