Waldenström's macroglobulinaemia

Waldenström’s macroglobulinaemia (also known as lymphoplasmacytic lymphoma) is a rare form of low-grade lymphoma (a type of bone marrow cancer), which is associated in most cases with the presence of an excessive amount of abnormal protein (called “paraprotein” or “M-protein”) in the blood. Due to the rarity of the condition, UCLH has the largest referral practice in the UK for this condition and IgM associated disorders.

Significant conditions

IgM monoclonal protein may be associated with a number of conditions (known as IgM monoclonal gammopathies of clinical significance, or IgM-associated disorders). These IgM monoclonal gammopathies of clinical significance are:

• Cold Agglutinin Disease (CAD)
• Paraprotein-associated neuropathies, including anti-MAG neuropathy
• Cryoglobulinaemia
• IgM associated renal impairment
• IgM associated acquired bleeding disorders
• IgM associated AL amyloidosis
• Schnitzler syndrome.

Paraprotein-associated or Paraproteinaemic neuropathy is a condition affecting the peripheral nerves, associated with the presence of a protein in the blood known as a paraprotein. The Joint Neuropathy Clinic, held weekly at the National Hospital for Neurology and Neurosurgery, together with Professor Michael Lunn, Consultant Neurologist with a specialist interest in inflammatory neuropathies, provides multi-specialist input for patients with this condition.

Neurohaematology service

Bing-Neel syndrome and paraprotein-associated neuropathy are conditions affecting the central or peripheral nervous system, associated with the presence of a protein in the blood known as a paraprotein. The Joint Neuropathy Clinic, held weekly at the National Hospital for Neurology and Neurosurgery, together with Professor Michael Lunn, Consultant Neurologist with a specialist interest in inflammatory neuropathies and central nervous system involvement by WM (Bing-Neel Syndrome) providing multi-specialist input for patients with this condition.