Waldenström’s macroglobulinaemia (also known as lymphoplasmacytic lymphoma) is a rare form of low-grade lymphoma (a type of bone marrow cancer), which is associated in most cases with the presence of an excessive amount of abnormal protein (called “paraprotein” or “M-protein”) in the blood. Due to the rarity of the condition, UCLH has the largest referral practice in the UK for this condition and IgM associated disorders.
IgM monoclonal protein may be associated with a number of conditions (known as IgM monoclonal gammopathies of clinical significance, or IgM-associated disorders). These IgM monoclonal gammopathies of clinical significance are:
- Cold Agglutinin Disease (CAD)
- Paraprotein-associated neuropathies, including anti-MAG neuropathy
- IgM associated renal impairment
- IgM associated acquired bleeding disorders
- IgM associated AL amyloidosis
- Schnitzler syndrome.
Paraprotein-associated or Paraproteinaemic neuropathy is a condition affecting the peripheral nerves, associated with the presence of a protein in the blood known as a paraprotein. The Joint Neuropathy Clinic, held weekly at the National Hospital for Neurology and Neurosurgery, together with Professor Michael Lunn, Consultant Neurologist with a specialist interest in inflammatory neuropathies, provides multi-specialist input for patients with this condition.
Bing-Neel syndrome and paraprotein-associated neuropathy are conditions affecting the central or peripheral nervous system, associated with the presence of a protein in the blood known as a paraprotein. The Joint Neuropathy Clinic, held weekly at the National Hospital for Neurology and Neurosurgery, together with Professor Michael Lunn, Consultant Neurologist with a specialist interest in inﬂammatory neuropathies and central nervous system involvement by WM (Bing-Neel Syndrome) providing multi-specialist input for patients with this condition.
Please refer to our recently published article on the diagnosis and management of IgM MGCS: Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM. IgM monoclonal gammopathies of clinical significance: diagnosis and management. Haematologica. 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953
Useful links: WMUK Charity
Other contact information
If you are a patient, please call the Patient Telephone Line for all queries: 0203 447 7359. Please note the line is open Monday to Friday 9am–5pm. Outside of office hours and for medical advice only, patients may call the haematology ward: 07852 220 900.
Please note this line is for patients only – medical professionals should call the general enquiries line for any patient-related queries.
UCLH Centre for Waldenström’s macroglobulinaemia and related conditions
University College Hospital
3rd Floor West
250 Euston Road
London NW1 2PG