Photo of Dr Ajenthan Surendranathan

Dr Ajenthan Surendranathan

Telephone:

Email:

Location:

  • National Hospital for Neurology and Neurosurgery

GMC/GDC number:

6077257

Professional background

Dr Surendranathan is an honorary consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, where he runs a specialist movement disorders clinic. He has a particular interest in cognitive disorders associated with Parkinsonism, including dementia with Lewy bodies and Parkinson’s disease dementia. He is also a consultant neurologist at West Hertfordshire Teaching Hospitals NHS Trust where he sees patients with all neurological disorders.

Dr Surendranathan qualified from the Barts and The London School of Medicine in 2003, having also completed an intercalated degree in Neuroscience at UCL. He was trained in general medicine at the Hammersmith, Guys and St Thomas’ and St Mary’s Hospital. His postgraduate training in Neurology was at Addenbrooke’s Hospital Cambridge, Queen’s Hospital, The Lister and the National Hospital for Neurology and Neurosurgery.

He was awarded a PhD in Clinical Neurosciences at the University of Cambridge for research investigating the role of Neuroinflammation in Lewy body dementia, as well as the clinical diagnosis and management of Parkinson’s disease dementia and dementia with Lewy bodies. 

Dr Surendranathan has also trained as a solicitor and practiced for Linklaters LLP in their capital markets group.

Specialties

Research interests

Dr Surendranathan’s research is focused on improving the diagnosis and management of Lewy body disorders. He is also interested in inflammation in the pathogenesis of dementia with Lewy bodies and Parkinson’s disease dementia, particularly the role of microglia. He has previously worked on the Diamond Lewy study funded by the NIHR as well as the neuroimaging of inflammation in memory and other disorders study at the University of Cambridge.

Publications

  • Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival. Strauss A, Swann P, Kigar SL, Christou R, Savinykh Yarkoni N, Turner L, Murley AG, Chouliaras L, Shapiro N, Ashton NJ, Savulich G, Bevan-Jones WR, Surendranthan A, Blennow K, Zetterberg H, O'Brien JT, Rowe JB, Malpetti M. Mol Psychiatry. 2025 May;30(5):1985-1994. doi: 10.1038/s41380-024-02809-w. Epub 2024 Oct 29. PMID: 39472664
  • Inflammation in dementia with Lewy bodies. Amin J, Erskine D, Donaghy PC, Surendranathan A, Swann P, Kunicki AP, Boche D, Holmes C, McKeith IG, O'Brien JT, Teeling JL, Thomas AJ. Neurobiol Dis. 2022 Jun 15;168:105698. doi: 10.1016/j.nbd.2022.105698. Epub 2022 Mar 18. PMID: 35314318.
  • Introduction of an assessment toolkit associated with increased rate of DLB diagnosis. Surendranathan A, Kane J, Bentley A, Barker S, McNally R, Bamford C, Taylor JP, Thomas A, McKeith I, Burn D, O'Brien JT. Alzheimers Res Ther. 2021 Feb 19;13(1):50. doi: 10.1186/s13195-021-00786-8. PMID: 33608039
  • Textbook of Immunopsychiatry: An Introduction (2021) Golam Khandaker (Editor), Neil Harrison (Editor), Edward Bullmore (Editor), Robert Dantzer (Editor); Chapter 10: Role of Inflammation in Lewy Body Dementia. A Surendranathan and J T O’Brien; p190-212.
  •  [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases. Mak E, Kouli A, Holland N, Nicastro N, Savulich G, Surendranathan A, Malpetti M, Manavaki R, Hong YT, Fryer TD, Aigbirhio F, Rowe JB, O'Brien JT, Williams-Gray CH.  Brain Commun. 2021 Aug 28;3(3):fcab177. doi: 10.1093/braincomms/fcab177. PMID: 34485906
  • Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months. Matar E, White SR, Taylor JP, Thomas A, McKeith IG, Kane JPM, Surendranathan A, Halliday GM, Lewis SJG, O'Brien JT. Neurology. 2021 Sep 7;97(10):e1031-e1040. doi: 10.1212/WNL.0000000000012450. PMID: 34404743
  • Improving the diagnosis and management of Lewy body dementia: the DIAMOND-Lewy research programme including pilot cluster RCT. O’Brien JT, Taylor JP, Thomas A, Bamford C, Vale L, Hill S, Allan L, Finch T, McNally R, Hayes L, Surendranathan A, Kane J, Chrysos AE, Bentley A, Barker S, Mason J, Burn D, McKeith I. Southampton (UK): NIHR Journals Library; 2021 Jul. PMID: 34339153.
  • Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography. Mak E, Nicastro N, Malpetti M, Savulich G, Surendranathan A, Holland N, Passamonti L, Jones PS, Carter SF, Su L, Hong YT, Fryer TD, Williams GB, Aigbirhio F, Rowe JB, O'Brien JT. Neurobiol Aging. 2021 May;101:172-180. doi: 10.1016/j.neurobiolaging.2020.11.006.
  • Altered structural connectivity networks in dementia with lewy bodies. Nicastro N, Mak E, Surendranathan A, Rittman T, Rowe JB, O'Brien JT. Brain Imaging Behav. 2021 Oct;15(5):2445-2453. doi: 10.1007/s11682-020-00444-x. Epub 2021 Jan 29. PMID: 33511557
  • Clinical diagnosis of Lewy body dementia. Surendranathan A, Kane JPM, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O'Brien JT. BJPsych Open. 2020 Jun 16;6(4):e61. doi: 10.1192/bjo.2020.44. PMID: 32539875
  • The revised Addenbrooke's Cognitive Examination can facilitate differentiation of dementia with Lewy bodies from Alzheimer's disease. Prats-Sedano MA, Savulich G, Surendranathan A, Donaghy PC, Thomas AJ, Rowe JB, Su L, O'Brien JT. Int J Geriatr Psychiatry. 2021 Jun;36(6):831-838. doi: 10.1002/gps.5483. Epub 2020 Dec 14. PMID: 33275793
  • Introduction of a Management Toolkit for Lewy Body Dementia: A Pilot Cluster-Randomized Trial.  O'Brien JT, McKeith IG, Thomas AJ, Bamford C, Vale L, Hill S, Allan L, Finch T, McNally R, Hayes L, Surendranathan A, Kane JPM, Dunn S, Bentley A, Barker S, Mason J, Burn D, Taylor JP. Mov Disord. 2021 Jan;36(1):143-151. doi: 10.1002/mds.28282. Epub 2020 Sep 22. PMID: 32960456.
  • Correlation of microglial activation with white matter changes in dementia with Lewy bodies. Nicastro N, Mak E, Williams GB, Surendranathan A, Bevan-Jones WR, Passamonti L, Vàzquez Rodrìguez P, Su L, Arnold R, Fryer TD, Hong YT, Aigbirhio FI, Rowe JB, O'Brien JT. Neuroimage Clin. 2020;25:102200. doi: 10.1016/j.nicl.2020.102200. Epub 2020 Jan 28. PMID: 32032816
  • Neuroinflammation, and Aβ in Dementia With Lewy Bodies: A Deep-Phenotyping Case Report. Mak E, Surendranathan A, Nicastro N, Aigbirhio F, Rowe J, O'Brien J. Imaging Tau, Mov Disord Clin Pract. 2018 Nov 8;6(1):77-80. doi: 10.1002/mdc3.12689. PMID: 30746421
  • 11 C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia. Nicastro N, Surendranathan A, Mak E, Rowe JB, O'Brien JT.  Ann Clin Transl Neurol. 2019 Oct;6(10):2133-2136. doi: 10.1002/acn3.50877. Epub 2019 Sep 10. PMID: 31507085
  • Early microglial activation and peripheral inflammation in dementia with Lewy bodies. Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, Vázquez Rodríguez P, Bevan-Jones WR, Brain SAE, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT. Brain. 2018 Dec 1;141(12):3415-3427. doi: 10.1093/brain/awy265. PMID: 30403785
  • Clinical prevalence of Lewy body dementia. Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O'Brien JT. Alzheimers Res Ther. 2018 Feb 15;10(1):19. doi: 10.1186/s13195-018-0350-6. PMID: 29448953
  • Clinical imaging in dementia with Lewy bodies. Surendranathan A, O'Brien JT. Evid Based Ment Health. 2018 May;21(2):61-65. doi: 10.1136/eb-2017-102848. Epub 2018 Mar 29. PMID: 29602778
  • In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease. Mak E, Bethlehem RAI, Romero-Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan-Jones RW, Passamonti L, Vázquez Rodríguez P, Su L, Arnold R, Williams GB, Hong YT, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT. Alzheimers Dement (Amst). 2018 Sep 17;10:678-687. doi: 10.1016/j.dadm.2018.08.005. PMID: 30426064
  • [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy. Passamonti L, Rodríguez PV, Hong YT, Allinson KSJ, Bevan-Jones WR, Williamson D, Jones PS, Arnold R, Borchert RJ, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB. Neurology. 2018 May 29;90(22):e1989-e1996. doi: 10.1212/WNL.0000000000005610. Epub 2018 Apr 27. PMID: 29703774
  • Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. Bevan-Jones WR, Surendranathan A, Passamonti L, Vázquez Rodríguez P, Arnold R, Mak E, Su L, Coles JP, Fryer TD, Hong YT, Williams G, Aigbirhio F, Rowe JB, O'Brien JT. BMJ Open. 2017 Jan 7;7(1):e013187. doi: 10.1136/bmjopen-2016-013187. PMID: 28064175
  • Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies. Mak E, Gabel S, Su L, Williams GB, Arnold R, Passamonti L, Vazquez Rodríguez P, Surendranathan A, Bevan-Jones WR, Rowe JB, O'Brien JT. Int Psychogeriatr. 2017 Apr;29(4):545-555. doi: 10.1017/S1041610216002143. Epub 2017 Jan 16. PMID: 28088928
  • 18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KS, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB. Brain. 2017 Mar 1;140(3):781-791. doi: 10.1093/brain/aww340. PMID: 28122879
  • Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. Su L, Faluyi YO, Hong YT, Fryer TD, Mak E, Gabel S, Hayes L, Soteriades S, Williams GB, Arnold R, Passamonti L, Rodríguez PV, Surendranathan A, Bevan-Jones RW, Coles J, Aigbirhio F, Rowe JB, O'Brien JT. Br J Psychiatry. 2016 Dec;209(6):525-526. doi: 10.1192/bjp.bp.116.190165. Epub 2016 Oct 6. PMID: 27758838
  • Neuroinflammation in Lewy body dementia. Surendranathan A, Rowe JB, O'Brien JT. Parkinsonism Relat Disord. 2015 Dec;21(12):1398-406. doi: 10.1016/j.parkreldis.2015.10.009. Epub 2015 Oct 9. PMID: 26493111
  • Rapid Paediatrics H. Brough, R. Alkurdi, R. Nataraja & A. Surendranathan. Blackwell Publishing. Published Oct 2004.