Professional background

Dr Trip studied at the University of Edinburgh Medical School and did postgraduate neurological training in London. He is a consultant neurologist and honorary associate professor and divides his time between the National Hospital for Neurology and Neurosurgery (NHNN) and Northwick Park Hospital. He is co-chair of the Queen Square multiple sclerosis centre and the NHNN's lead consultant for audit & quality improvement.

At the NHNN, he jointly runs a multiple sclerosis clinic with Dr Declan Chard. This is a large clinic for patients with multiple sclerosis and other related CNS inflammatory disorders such as neuromyelitis optica spectrum disorder (NMOSD).

He also has a general neurology clinic and looks after in-patients at the NHNN.

At Northwick Park, he has general neurology clinics, offers an in-patient neurology consultation service to other clinicians, and provides neurological input to the Regional Rehabilitation Unit.

He is actively involved in undergraduate & postgraduate training.

Research interests

Dr Trip completed a PhD at the UCL Institute of Neurology which looked at markers of axonal loss and myelination in patients with optic neuritis.

He is co-chair of the Queen Square multiple sclerosis centre and honorary associate professor in neurology at UCL. He supervises a PhD student and is involved in research studies and clinical trials for patients with optic neuritis, MS and NMOSD.

Publications

Kleerekooper I, Petzold A, Trip SA. Anterior visual system imaging to investigate energy failure in multiple sclerosis. Brain. 2020 Mar 12. pii: awaa049.

UCL Queen Square National Hospital for Neurology and Neurosurgery COVID-19 Study Group. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020 Jul 8:awaa240. doi: 10.1093/brain/awaa240.

Lim ST, Janaway B, Costello H, Trip SA, Price G. Persistent Psychotic Symptoms following Covid-19 Disease.BJPsych Open. 2020 Jul 22:1-11.

Kleerekooper I, Herbert MK, Kuiperij HB, Sato DK, Fujihara K, Callegaro D, Marignier R, Saiz A, Senel M, Tumani H, De Jong BA, Trip SA, Nakashima I, Verbeek MM, Petzold A. CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD. J Neurol Neurosurg Psychiatry. 2020 Jun;91(6):605-611. doi: 10.1136/jnnp-2019-322286.

Marshall J, Kleerekooper I, Davagnanam I, Trip SA. Acute anosmia in neuromyelitis optica spectrum disorder. Mult Scler. 2020 Mar 31:1352458520907909.

Chard DT, Trip SA. An asymptomatic new lesion on MRI is a relapse and should be treated accordingly - No. Mult Scler. 2019 Dec;25(14):1843-1845.Li V, McArdle H, Trip SA. Easily missed – Vestibular migraine. BMJ. 2019 Jul 3;366:l4213. doi: 10.1136/bmj.l4213.

Whiteside DJ, Trip SA. Reader response: Rare side effects of alemtuzumab remind us of the need for postmarketing surveillance. Neurology. 2019 Mar 19;92(12):585.De Angelis F, Brownlee WJ, Chard DT, Trip SA. New MS diagnostic criteria in practice. Pract Neurol. 2019 Feb;19(1):64-67Whiteside D, Barth S, Datta A, Trip SA. Pneumonitis secondary to alemtuzumab in a patient with multiple sclerosis - A non-infectious cause of breathlessness. Mult Scler Relat Disord. 2018 Apr 3;22:139-140.Chard DT, Trip SA. Resolving the clinico-radiological paradox in multiple sclerosis. F1000Res. 2017 Oct 12;6:1828.
Baheerathan A, Brownlee WJ, Rugg-Gunn F, Chard DT, Trip SA. Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide. Mult Scler Relat Disord. 2017 Apr;13:73-74.

Brownlee WJ, Baheerathan A, Rugg-Gunn F, Chard DT, Trip SA. Commentary on: Neuromyelitis optica spectrum disorder related tonic spams responsive to lacosamide - Authors reply. Mult Scler Relat Disord. 2017 Oct;17:146-147.

Baheerathan A, Brownlee WJ, Chard DT, Shields K, Gregory R, Trip SA.  Antecedent anti-NMDA receptor encephalitis in two patients with multiple sclerosis. Mult Scler Relat Disord. 2017 Feb;12:20-22.

Wang JJ, Jaunmuktane Z, Mummery C, Brandner S, Leary S, Trip SA. Inflammatory demyelination without astrocyte loss in MOG antibody positive NMOSD. Neurology 2016;87(2)229-231.

Chard D, Trip A, Chataway J. New oral drugs for multiple sclerosis. British Journal of Hospital Medicine 2016; 2016 Sep 2;77(9):502-3.

Henderson, A., Trip, S., & Miller, D. (2015). Optical coherence tomography in acute optic neuritis. In P. Calabresi, L. Balcer, & E. Frohman (Eds.), Optical Coherence Tomography in Neurologic Diseases (pp. 28-41). Cambridge: Cambridge University Press.

McCluskey G, Rajani CK, Lewis G, Kaushal V, Gardiner PV, Jee P, Trip A, McCarron MO, de Wolff JF. Two different presentations, one diagnosis. Acute Med. 2014;13(3):121-5.

Sommerlad A, Price G, Trip A. Management of neuropsychiatric symptoms in multiple sclerosis. Progress in Neurology and Psychiatry 2014;18(2):14-19.

Raftopoulos R, Trip A. The Application of Optical Coherence Tomography (OCT) in Neurological Disease. ACNR 2012;12(2):30-33.

Trip SA, Reilly MM et al. Chronic inflammatory sensory polyradiculopathy with cranial nerve involvement. J Neurol. 2012; 259(6):1238-40.

Henderson AP, Altmann DR, Trip SA, Miszkiel KA, Schlottmann PG, Jones SJ, Garway-Heath DF, Plant GT, Miller DH. Early factors associated with axonal loss after optic neuritis. Annals of Neurology 2011; 2011: 70(6):955-63.

Henderson AP, Altmann DR, Trip SA, Kallis C, Jones SJ, Schlottmann PG, Garway-Heath DF, Plant GT, Miller DH. A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials. Brain 2010;133(9):2592-602

Trip SA, Schlottmann PG, Jones SJ, Kallis C, Altmann DR, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH. Scanning laser polarimetry quantification of retinal nerve fiber layer thinning following optic neuritis. Journal of Neuro-Ophthalmology 2010;30(3):235-42..

Henderson APD, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, Miller DH. A preliminary longitudinal study of the retinal nerve fibre layer in progressive multiple sclerosis. J Neurol. 2010;257(7):1083-91

Blakely EL, Trip SA, Swalwell H, He L, Wren DR, Rich P, Turnbull DM, Omer SE, Taylor RW. A new mitochondrial tRNAPro gene mutation associated with MERRF and other neurological features. Archives of Neurology 2009;66(3):399-402.

Henderson APD, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, Miller DH. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain 2008;131:277-87.

Sheerin UM, Trip A, Schon F. Atrophy of the superior oblique muscle. Practical Neurol 2008;8(2):122-3.

Trip SA, Schlottmann PG, Jones SJ, Li WY, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH. Optic nerve magnetisation transfer imaging and measures of axonal loss and demyelination in optic neuritis. Multiple Sclerosis 2007;13(7):875-9.

Wheeler-Kingshott CA, Trip SA, Symms MR, Parker GJ, Barker GJ, Miller DH. In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls. Magn Reson Med 2006;56:446-51.

Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH. Quantification of optic nerve head topography in optic neuritis: a pilot study. British Journal of Ophthalmology 2006;90:1128-31.

Trip SA, Schlottmann PG, Jones SJ, Li WY, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH. Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy. Neuroimage 2006;31:286-293.

Trip SA, Wheeler-Kingshott C, Jones SJ, Li WY, Barker GJ, Thompson AJ, Plant GT, Miller DH. Optic nerve diffusion tensor imaging in optic neuritis. Neuroimage 2006;30:498-505.

Frohman E, Costello F, Zivadinov R, Stuve O, Conger A, Winslow H, Trip A, Frohman T, Balcer L. Optical coherence tomography in multiple sclerosis. Lancet Neurology 2006;5(10):853-63.

Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Annals of Neurology 2005;58:383-391.

Coles AJ, Cox A, Le Page E, Jones J, Trip SA, Deans J, Seaman S, Miller DH, Hale G, Waldmann H, Compston DA. The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy. Journal of Neurology 2005;253(1):98-108.

Trip SA, Miller DH. Imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry 2005; 76 Suppl 3 (Neurology in Practice): iii11-iii18.

Trip SA, Wroe SJ. Primary Orthostatic Tremor Associated with a Persistent Cerebrospinal Fluid Monoclonal IgG Band. Movement Disorders 2003;18:345-346.

Trip SA, Wroe SJ, Davies GR, Giovannoni G. Primary CNS mantle cell lymphoma associated with an isolated CSF monoclonal IgG band. European Neurology 2003;49:187-188.

Trip SA, Naryanaswamy HM, Wroe SJ. An acute disseminated encephalomyelitis-like illness following alcohol withdrawal. Hospital Medicine 2003;64:620-621.

Van Kempen GThH, Trip SA, Molenaar PC. Acetylcholinesterase activity of skeletal muscle in a non-immunogenic model for myasthenia gravis in rats. Journal of Neural Transmission 1999;106:423-431.