Photo of Dr Giacomo Chiaro

Dr Giacomo Chiaro

Email:

Location:

  • National Hospital for Neurology and Neurosurgery

GMC/GDC number:

7964441

Professional background

Dr Chiaro obtained his MD at the University of Bologna, Italy. He pursued post-graduate neurology training at the Neurocentre of Southern Switzerland in Lugano, Switzerland. He has two subspecialties in sleep medicine (European Sleep Research Society) and EEG (Swiss Society of Clinical Neurophysiology). He completed a clinical fellowship in autonomic neurology at the National Hospital for Neurology and Neurosurgery.

Since 2024, Dr Chiaro has served as a consultant neurologist at the Autonomic Unit. His responsibilities include running specialist autonomic clinics, providing care to inpatients with autonomic disorders, and leading a weekly autonomic Multidisciplinary Team (MDT) meeting. He is the consultant lead for the autoimmune autonomic disorders clinic.

Specialties

Research interests

His current research activity focuses on the early diagnosis of autonomic failure in neurodegenerative diseases. He regularly participates in clinical trials. The results of his research have been published in peer-reviewed journals such as Brain, Nature, NPJ, and Sleep.

Languages spoken

English, Italian, German, French, Spanish, Portuguese

Publications

  1. Chiaro G, Vichayanrat E, Koay S, Rogeau S, Ingle G, McNamara P, Watson L, Bomanji J, Mathias CJ, Iodice V. Pure autonomic failure: a natural history study of the Queen Square cohort. Brain 2025 
  2. Sander L, Oommen G, Brophy C, Bohus-Roper S, Chiaro G, Bremner F, Iodice V. Validation of Monocular Pupillometry in Healthy Controls and Patients With Autonomic Dysfunction: Pupillary Biomarkers for Autonomic Failure. Eur J Neurol 2025 
  3. Koay S, Vichayanrat E, Bremner F, Valerio F, Mackenzie R, Chiaro G, Ingle G, McNamara P, Watson L, Panicker J, Lunn M, Mathias. Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure. Ann Clin Trans Neurol 2025 
  4. Sander L, Chiaro G, Abelardo D, Torrente A, Ingle G, McNamara P, Watson P, Whelan C, Gillmore J, Reilly M, Mathias CJ, Iodice V. Early cardiovascular autonomic failure in ATTRv predicts poor prognosis and may respond to disease-modifying therapy. Amyloid 2025 
  5. Chiaro G, Stancanelli C, Koay S, Vichayanrat E, Sander L, Ingle G, McNamara P, Carr A, Wechalekar A, Whelan C, Gillmore J, Hawkins P, Reilly M, Mathias C, Iodice V. Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker. Clinical Autonomic Research 2024 
  6. Pinton S, Vacchi E, Chiaro G, Raimondi A, Tzankov A, Gerber B, Gobbi C, Kaelin-Lang A, Melli G. Amyloid detection and typing yield of skin biopsy in systemic amyloidosis and polyneuropathy. ACTN 2023 
  7. Vacchi E, Lazzarini E, Pinton S, Chiaro G, Disanto G, Marchi F, Robert T, Staedler C, Galati S, Gobbi C, Barile L, Kaelin-Lang A, Melli G. Tau protein quantification in skin biopsies differentiates tauopathies from alpha synucleinopathies. Brain 2022 
  8. Vacchi E, Senese C, Chiaro G, Disanto G, Pinton S, Morandi S, Bertaina I, Bianco G, Staedler C, Galati S, Gobbi C, Kaelin-Lang A, Melli G. Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson's disease. Parkinsons Dis 2021 
  9. Zitser J, During EH, Chiaro G, Miglis MG. Autonomic impairment as a potential biomarker in idiopathic REM-sleep-behavior disorder. Aut Neurosci 2019 
  10. Chiaro G, Calandra-Buonaura G, Cecere A, Mignani F, Sambati L, Loddo G, Cortelli P, Provini F. REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand? Clin Aut Res 2017 
  11. Donadio V, Liguori R, Incensi A, Chiaro G, Bartoletti-Stella A, Capellari S, Cortelli P. Skin biopsy and microneurography disclose selective noradrenergic dysfunction due to dopamine-β-hydroxylase deficiency. Aut Neurosci 2016