Dr Lydia Lee details
Telephone:
GMC/GDC number:
6106355
Professional background
Dr Lydia Lee graduated from UCL in 2004 and completed her Clinical Haematology training in the North West London Rotation. She completed her PhD in CAR-T cell therapy for Multiple Myeloma in the labs of Prof Kwee Yong and Dr Martin Pule at the UCL Cancer Institute. During her PhD, she developed the first myeloma CAR-T cell trial to enter clinical trials in Europe, and has subsequently opened the first academic CAR-T cell trial in the UK for myeloma and also for AL amyloidosis. She is a consultant haematology at UCLH seeing patients with myeloma and also runs a research laboratory group at the UCL Cancer Institute.
Specialties
Research interests
Multiple Myeloma, CAR-T cell, Immunotherapy
Publications
- Contrasting outcomes and use of desmosine to monitor two patients treated with plasma cell-directed chemotherapy for gammopathy driven pulmonary elastolysis in acquired cutis laxa. Front. Hematol., 23 June 2025. Lydia Lee, Emma Fosbury, Rakesh Popat, Kwee Yong, Ashutosh Wechalekar, Jeremy S. Brown, Jeffrey Huang, Sandy Mcbride and John R. Hurst
- Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia. Sci Transl Med. 2025 Apr 16. Nicola Maciocia, Malika Hoekx, Ciaran Acuna, Brandon Wade, Amy Burley, Saumya Ramanayake, Francesco Nannini, Patrycja A Wawrzyniecka, Thaneswari Karpanasamy, Maria Schuldt, Stephanie Ng, Mathieu Ferrari, Teresa Marafioti, Giuseppe Gritti, Shimobi Onuoha, David O'Connor, Lydia Lee, Marc Mansour, Asim Khwaja, Martin Pule, Paul Maciocia
- Single-cell profiling of human bone marrow reveals multiple myeloma progression is accompanied by an increase in CD56bright bone marrow resident NK cells. bioRxiv 2025.02.26.640356. Elise Rees, Isabella Sodi, Kane Foster, Louise Ainley, Emma Lyon, Daria Galas-Filipowicz, Jasmin Rahman, Rebekah Allen, Jessica Kimber, Aditya Prabu, Gwennan Ward, Dylan Jankovic, Annabel Laidler, Bethan Hudson-Lund, Selina Chavda, Catherine Lecat, Daniel Hughes, Ambreen Rashid, Grant Vallance, Ceri Bygrave, Dean Smith, Firas Al-Kaisi, Fenella Willis, Christopher Parrish, Lydia Lee, Karthik Ramasamy, Francesco Colucci, Eileen M. Boyle, Kwee Yong
- Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T cell therapy Journal Immunotherapy Cancer. 2023 Jun;11(6):e006699 L Lee, WC Lim, D Galas-Filipowicz, K Fung, J Taylor, D Patel, Z Akbar, E Alvarez Mediavilla, P Wawrzyniecka, D Shome, RM Reijmers, T Gregg, L Wood, W Day, V Cerec, M Ferrari, S Thomas, S Cordoba, S Onuoha, N Khokhar, V Peddareddigari, M Al-Hajj, J Cavet, S Zweegman, M Rodriguez-Justo , K Yong , MPule , R Popat
- Under-representation of ethnic minorities in early phase clinical trials for multiple myeloma. Haematologica 2022 Dec 107(12)2961-2965. Asher S, Kazantzi A, Dekaj F, Steventon L, Khatun A, Ainley L, McMillan A, Rabin N, Wechalekar A, Sive J, Kyriakou C, Papanikolaou X, Xu K, Mahmood S, Wisniowski B, Lee L, Yong K, Popat R.
- Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia. Blood 2022 July 140(1) 25-37. Maciocia PM, Wawrzyniecka PA, Maciocia NC, Burley A, Karpanasamy T, Devereaux S, Hoekx M, O'Connor D, Leon T, Rapoz-D'Silva T, Pocock R, Rahman S, Gritti G, Yánez DC, Ross S, Crompton T, Williams O, Lee L, Pule MA, Mansour MR.
- BCMA CARs in multiple myeloma: room for more? Blood. 2021 May 27;137(21):2859-2860. Lee L, Yong KL.
- Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma. Front Immunol. 2021;12:618610. Lee L, Alrasheed N, Khandelwal G, Fitzsimons E, Richards H, Wilson W, Chavda SJ, Henry J, Conde L, De Massy MR, Chin M, Galas-Filipowicz D, Herrero J, Chain B, Quezada SA, Yong K.
- Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4 + PD-1 + Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma. Clin Cancer Res, 2020 Jul 1;26(13):3443-3454. Nouf Alrasheed , Lydia Lee , Ehsan Ghorani , Jake Y Henry , Lucia Conde , Melody Chin , Daria Galas-Filipowicz , Andrew J S Furness , Selina J Chavda , Huw Richards, Dunnya De-Silva, Oliver C Cohen , Dominic Patel , Anthony Brooks , Manuel Rodriguez-Justo , Martin Pule , Javier Herrero , Sergio A Quezada , Kwee L Yong
- An APRIL based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma has potent activity in vitro and in vivo. Blood, 2018 Feb 15;131(7):746-758. Lee L, Draper B, Chaplin N, Philip B, Chin M, Galas-Filipowicz D, Onuoha S, Thomas S, Balden V, Bughda R, Maciocia P, Kokalaki E, Neves M, Patel D, Rodriguez-Justo M, Francis J, Yong K, Pule M
- Evaluation of B cell maturation antigen as a target for antibody drug conjugate mediated cytotoxicity in multiple myeloma. British Journal of Haematology, 2016 Sep;174(6):911-22. Lee L, Bounds D, Paterson J, Herledan G, Sully K, Seestaller-Wehr LM, Fieles WE, Tunstead J, McCahon L, Germaschewski FM, Mayes PA, Craigen JL, Rodriguez-Justo M, Yong KL.
- Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia. Clinical Medicine Insights: Oncology 2012:6 85-100. Lee L, Fielding A.
- Coexistent asymptomatic myeloma and hereditary cardiac amyloidosis: an unusual case of heart failure.British Journal of Hospital Medicine. 2011 Nov;72(11):650-1. Lee L, Aziz M, Wechalekar A, Rabin N.
- A Simple Case of Heart Failure? British Journal of Hospital Medicine. 2008 March, 69(3):167. Lee L, Donaldson A, Lok S
- Sequence variability of the alpha-chemokine UL146 from clinical strains of human cytomegalovirus. J Med Virol. 2004 Dec;74(4):573-9. Hassan-Walker AF, Okwuadi S, Lee L, Griffiths PD, Emery VC.
- Genetic content of wild-type human cytomegalovirus. J Gen Virol. 2004 May;85(Pt 5):1301-12. Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ.