Professional background

Dr Nick Losseff is a consultant neurologist at The National Hospital for Neurology and Neurosurgery and UCL Hospitals.

He qualified from St Thomas' Hospital in London and trained in neurology at Kings, St Thomas, UCH and The National Hospital for Neurology and Neurosugery. He was previously awarded the Queen Square Prize in Neurology and The European Neurology Society Prize.

Dr Losseff has been a consultant since 2000 and runs a very active "general" neurology practice (diagnosis and treatment of headache, migraine, seizures, dizziness, funny turns, numbness, etc). He sub-specialises in the assessment and management of stroke and TIA.

He has held several senior leadership positions in the NHS to medical director level, and is best known for his work to improve stroke services in London. He was previously clinical director of the UCLH Comprehensive Stroke Service 2007-13 and the London clinical director for Stroke in 2009. He was appointed by NHS England as the London clinical cirector for neuroscience in 2013.

He is listed in the Tatler Doctors Guide as one of Britains top 250 consultants, where he is described as "highly experienced and renowned for his comforting bedside manner".

Research interests

General neurology, stroke, AVM's


Lessons from running a neurology strategic clincial network.
Losseff N
Advances in Clinical Neuroscience and Rehabilitation - 2017;16:20-24

Challenging Hunt on strokes.
Collaborative authors
Sunday Times - letters Jan 17 2016.

Cerebral involvement in IgG4-related disease.
Joshi D, Jager R, Hurel S, Pereira SP, Johnson GJ, Chapman M, Fowler R, Winstanley A, Losseff N, Webster GJ.
Clinical Medicine. 2015:130-4.

Successful thrombolysis of stroke with intravenous alteplase in the third trimester of pregnancy.
Mantoan Ritter L, Schüler A, Gangopadhyay R, Mordecai L, Arowele O, Losseff N,
O' Brien P, Dewan B.
Journal of Neurology. 2014;261:632-4.

Can cerebral microbleeds cause an acute stroke syndrome?
Teo JT, Ramadan H, Gregoire SM, Mufti S, Lipman G H. Jager RH, Losseff NA, and Werring D
Neurology Clinical Practice 2011;1 75-77.

Cerebral venous sinus thrombosis may be associated with clozapine.
Werring D, Hacking D, Losseff N, Jäger HR, Walsh M, Foong J.
J Neuropsychiatry Clin Neurosci. 2009; 21:343-5.

Priorities in stroke care. The London stroke strategy.
Losseff N, Ames D, Cloud G, Cluckie G, Gompertz P, Grant B, Markus H, Brown MM.
BMJ. 2009 Jun 29;338:b2616.

The role of the thalamus in amnesia: a tractography, high-resolution MRI and neuropsychological study.
Cipolotti L, Husain M, Crinion J, Bird CM, Khan SS, Losseff N, Howard RS, Leff AP.
Neuropsychologia. 2008 Sep;46(11):2745-58.

Neurological picture. Varicella zoster virus and intracranial dolichoectasia in a late adult cancer survivor.
Dalton CM, Jäger HR, Losseff NA, Greenwood RJ.
J Neurol Neurosurg Psychiatry. 2008 May;79(5):573.

Subarachnoid haemorrhage as the first clinical manifestation of Churg-Strauss syndrome.
Sheerin UM, Barreto J,Brown MM, Brew S, Losseff NA.
Journal of Neurology. 2008 Apr;255(4):607-8.

Haematology and neurology.
Austin S, Cohen H, Losseff N.
J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):334-41. Free PMC article

Cerebral microbleeds are common in ischemic stroke but rare in TIA.
Werring DJ, Coward LJ, Losseff NA, Jäger HR, Brown MM.
Neurology. 2005 Dec 27;65(12):1914-8.

A study of acute rehabilitation after head injury.
Greenwood RJ, Strens LH, Watkin J, Losseff N, Brown MM.
Br J Neurosurg. 2004 Oct;18(5):462-6.

A case of restless legs syndrome in association with stroke.
Anderson KN, Bhatia KP, Losseff NA.
Sleep. 2005 Jan 1;28(1):147-8.

Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI.
Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, Brown MM, Jäger HR.
Brain. 2004 Oct;127(Pt 10):2265-75. Free Article

Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis.
Furrows SJ, Hartley JC, Bell J, Silver N, Losseff N, Stevenson S, Chapman M, Thompson EJ, Ridgway GL, Giovannoni G.
J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):152-4. Free PMC article

Cognitive dysfunction after isolated brain stem insult. An underdiagnosed cause of long term morbidity.
Garrard P, Bradshaw D, Jäger HR, Thompson AJ, Losseff N, Playford D.
J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):191-4. Free PMC article

Shortening inpatient stay for stroke.
Edwards SG, Thompson AJ, Losseff N, Playford ED.
Lancet. 2002 Jun 22;359(9324):2205.

T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow-up study.
Sailer M, Losseff NA, Wang L, Gawne-Cain ML, Thompson AJ, Miller DH.
Eur J Neurol. 2001 Jan;8(1):37-42.

T1 hypointensity of the spinal cord in multiple sclerosis.
Losseff NA, Wang L, Miller DH, Thompson AJ.
J Neurol. 2001 Jun;248(6):517-21 .

Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis.
Giovannoni G, Miller DH, Losseff NA, Sailer M, Lewellyn-Smith N, Thompson AJ, Thompson EJ.
J Neurol. 2001 Jun;248(6):487-95.

The predictive value of gadolinium enhancement for long term disability in relapsing-remitting multiple sclerosis--preliminary results.
Losseff NA, Miller DH, Kidd D, Thompson AJ.
Mult Scler. 2001 Feb;7(1):23-5.

The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis. European Study Group on Interferon beta-1b in secondary progressive multiple sclerosis.
Molyneux PD, Kappos L, Polman C, Pozzilli C, Barkhof F, Filippi M, Yousry T, Hahn D, Wagner K, Ghazi M, Beckmann K, Dahlke F, Losseff N, Barker GJ, Thompson AJ, Miller DH.
Brain. 2000 Nov;123 ( Pt 11):2256-63. Free Article

MRI of the intraorbital optic nerve in patients with autosomal dominant optic atrophy.
Votruba M, Leary S, Losseff N, Bhattacharya SS, Moore AT, Miller DH, Moseley IF.
Neuroradiology. 2000 Mar;42(3):180-3.

Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI.
Fox NC, Jenkins R, Leary SM, Stevenson VL, Losseff NA, Crum WR, Harvey RJ, Rossor MN, Miller DH, Thompson AJ.
Neurology. 2000 Feb 22;54(4):807-12.

Texture analysis of spinal cord pathology in multiple sclerosis.
Mathias JM, Tofts PS, Losseff NA.
Magn Reson Med. 1999 Nov;42(5):929-35.

Spinal cord atrophy and disability in MS: a longitudinal study.
Stevenson VL, Leary SM, Losseff NA, Parker GJ, Barker GJ, Husmani Y, Miller DH, Thompson AJ.
Neurology. 1998 Jul;51(1):234-8. Free Article

Measures of brain and spinal cord atrophy in multiple sclerosis.
Losseff NA, Miller DH
J Neurol Neurosurg Psychiatry. 1998 May;64 Suppl 1:S102-5

Asymptomatic spinal cord lesions in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of demyelination.
O'Riordan JI, Losseff NA, Phatouros C, Thompson AJ, Moseley IF, MacManus DG, McDonald WI, Miller DH.
J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):353-7. Free PMC article

Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH, Comi G, Adèr HJ, Losseff N, Valk J.
Brain. 1997 Nov;120 ( Pt 11):2059-69. Free Article

Magnetisation transfer ratio measurement in the cervical spinal cord: a preliminary study in multiple sclerosis.
Silver NC, Barker GJ, Losseff NA, Gawne-Cain ML, MacManus DG, Thompson AJ, Miller DH.
Neuroradiology. 1997 Jun;39(6):441-5.

Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Losseff NA, Wang L, Lai HM, Yoo DS, Gawne-Cain ML, McDonald WI, Miller DH, Thompson AJ.
Brain. 1996 Dec;119 ( Pt 6):2009-19. Free Article

Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression.
Losseff NA, Webb SL, O'Riordan JI, Page R, Wang L, Barker GJ, Tofts PS, McDonald WI, Miller DH, Thompson AJ.
Brain. 1996 Jun;119 ( Pt 3):701-8 Free Article

Clinical and magnetic resonance imaging predictors of disability in primary and secondary progressive multiple sclerosis.
Losseff NA, Kingsley DP, McDonald WI, Miller DH, Thompson AJ.
Mult Scler. 1996 Feb;1(4):218-22

Manifestations of central nervous system involvement in Guillain—Barré syndrome: clinical, MRI and EEG findings.
Losseff, N.A., Miller, D.H., Fletcher, N., Hirsch, N.P., Thorpe, J.W. and Howard, R.S., 1
European Journal of Neurology. 1996 3(5), p480.

The benefit of inpatient neurorehabilitation in multiple sclerosis.
Kidd D, Howard RS, Losseff NA, Thompson AJ.
Clinical Rehabilitation. 1995 (9):198-203

The medical management of increased tone.
Losseff NA, Thompson AJ.
Physiotherapy. 1995 (81):480-84

Magnetisation transfer ratios and transverse magnetisation decay curves in optic neuritis: correlation with clinical findings and electrophysiology.
Thorpe JW, Barker GJ, Jones SJ, Moseley I, Losseff N, MacManus DG, Webb S, Mortimer C, Plummer DL, Tofts PS, et al.
J Neurol Neurosurg Psychiatry. 1995 Nov;59(5):487-92. Free PMC article

Management of mitochondrial disease on an intensive care unit.
Howard RS, Russell S, Losseff N, Harding AE, Hughes JM, Wiles CM, Miller DH, Hirsch NP.
QJM. 1995 Mar;88(3):197-207

Primary CNS lymphoma.
Losseff N, Palace J.
Br J Hosp Med. 1993 Dec 15-1994 Jan 18;50(11):678-9.

Isolated dysphagia due to polymyositis.
Palace J, Losseff N, Clough C.
Muscle Nerve. 1993 Jun;16(6):680-1