Professional background

Dr Valeria Iodice is consultant in neurology and autonomic medicine and associate professor in neurology at University College London. Dr Iodice has been the clinical and academic lead of the autonomic unit at the National Hospital for Neurology and Neurosurgery, Queen Square, London since 2013.

She has longstanding clinical and research interests in autonomic neurology, gained in three worldwide autonomic centres: Mayo Clinic, Rochester USA; Imperial College London and The National Hospital for Neurology and Neurosurgery, London, UK.

Dr Iodice qualified at University Federico II, Medical College, Naples, Italy in 2003 and completed the residency in Neurology and Neurophysiology at the University Federico II, Naples, Italy in 2008.

She was award a clinical research fellowship in autonomic medicine at Mayo Clinic Rochester Minnesota (USA) in 2007 where she began her research on the autonomic nervous system (ANS) at the Autonomic Translational Centre, Mayo Clinic.

In 2009, she was award the first Sir Roger Bannister fellowship in autonomic disorders and was awarded with a PhD in neuroscience and autonomic neurology from Imperial College, London.

A respected speaker, she has presented at national and International meetings. Dr Iodice has written several publications in major specialist journals that focus on the ANS in neurology and cardiovascular disorders and chapters in international textbooks of neurological and cardiovascular medicine.

Specialties

Research interests

Novel biomarkers for early diagnosis of autonomic disorders, pathophysiology and treatment of emerging diseases, including autoimmune autonomic disorders, alpha synucleinopathies, metabolic disorders, amyloidosis and hereditary autonomic neuropathies and postural tachycardia syndrome.

Languages spoken

Italian

Publications

  1. Iodice V et al. Spinal cord lesion and dysautonomia. Autonomic nervous system and Sleep. Chokroverty an Cortelli Editors. Spinger
     
  2. Iodice V. and Mathias CJ. A tertiary referral centre for PoTS: The Autonomic Unit at the National Hospital for Neurology and Neurosurgery experience. Postural tachycardia syndrome: a concise and practical guide to management and associated condition. Springer 2020, Pages 303-308
     
  3. Mathias CJ., Iodice V., Low D and Galizia G. Orthostatic hypotension and Orthostatic Intolerance. Endocrinology, Adult and Pediatric. J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD. 7th Edition. Elsevier, 2015.
     
  4. Investigations of autonomic disorders. Mathias CJ., Bannister R. Editors: Autonomic Failure : A Texbook of Clinical Disorders of the Autonomic Nervous System. 5th Edition. Oxford University Press, Oxford, 2011.
     
  5. Bannister R., Iodice V., and Mathias C.J. Management of postural hypotension. Mathias CJ., Bannister R. Editors: Autonomic Failure : A Texbook of Clinical Disorders of the Autonomic Nervous System. 5th Edition. Oxford University Press, Oxford, 2011.
     
  6. Bannister R., Iodice V., Vichayanrat E., and Mathias C.J. Clinical features and evaluation of the primary chronic autonomic failure syndromes. Mathias CJ., Bannister R. Editors: Autonomic Failure : A Texbook of Clinical Disorders of the Autonomic Nervous System. 5th Edition. Oxford University Press, Oxford, 2011.
     
  7. Mathias CJ., Low D., Iodice V., and Bannister R. Investigations of autonomic disorders. Mathias CJ., Bannister R. Editors: Autonomic Failure : A Texbook of Clinical Disorders of the Autonomic Nervous System. 5th Edition. Oxford University Press, Oxford, 2011.
     
  8. Iodice V., Low D., Vichayanrat E., and Mathias CJ. Cardiovascular Autonomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes. Eds. M. Ebadi and R.F. Pfeiffer. Florida: CRC Press. 2011.
     
  9. Iodice, V, Vernino, S, Kimpinski, K, Sandroni, P, Fealey, RD, Low, PA. (2009) Autoimmune Autonomic Ganglionopathy: Response to Immunomodulatory Therapy. In: Dyck, P.J. Companion to Peripheral Neuropathy. USA: Elsevier.

 

Peer-Reviewed Articles

  1. Jenny L L CsecsValeria IodiceCharlotte L RaeAlice BrookeRebecca SimmonsLisa QuadtGeorgia K SavageNicholas G DowellFenella ProwseKristy ThemelisChristopher J MathiasHugo D CritchleyJessica A Eccles. Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain. Front Psychiatry. 2022 Feb 2;12:786916.
     
  2. Vincenzo ProviteraValeria IodiceFiore ManganelliStefania MozzilloGiuseppe CaporasoAnnamaria StancanelliIlaria BorrecaMarcello EspositoRaffaele DubbiosoRosa IodiceFloriana VitaleShiwen KoayEkawat VichayanratFernanda ValerioLucio SantoroMaria Nolano. Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease: A Morpho-functional Study. Neurology 2022 Jan 11.
     
  3. Jenny L L Csecs , Nicholas G Dowell , Georgia K SavageValeria Iodice , Christopher J MathiasHugo D CritchleyJessica A Eccles . Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health. Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):500-509.
     
  4. Ekawat VichayanratClaire HentzenAmit BatlaSara SimeoniValeria IodiceJalesh N Panicker. Lower urinary tract dysfunction in Parkinsonian syndromes Neurol Sci, 2021 Oct;42(10):4045-4054.
     
  5. Andrew P. Owens, Christopher J. Mathias, Valeria Iodice. Autonomic Dysfunction in Autism Spectrum Disorder. Front Integr Neurosci. 2021; 15
     
  6. William P CheshireRoy FreemanChristopher H GibbonsPietro CortelliGregor K WenningMax J HilzJudith M SpiesAxel LippPaola SandroniNaoki WadaAkiko ManoHyun Ah KimKurt KimpinskiValeria IodiceJuan IdiáquezPariwat ThaisetthawatkulElizabeth A CoonPhillip A LowWolfgang Singer.  Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol 2021 Feb;132(2):666-682.
     
  7. Koay S, Vichayanrat E, Bremner F, Panicker JN, Lang B, Lunn MP, Watson L, Ingle GT, Hagen EM, McNamara P, Jacobson L, Provitera V, Nolano M, Vincent A, Mathias CJ, Iodice V. Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy. Ann Neurol, 2021 Apr;89(4):753-768.
     
  8. Pellecchia et al. Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group. Movement disorders clinical practice 2020; 7(7): 750–762
     
  9. Chelban et al. An update on MSA: premotor and non-motor features open a window of opportunities for early diagnosis and intervention. J Neurol, 2020 Sep;267(9):2754-2770.
     
  10. Panicker JN, Simeoni S, Miki Y, et al Early presentation of urinary retention in multiple system atrophy: can the disease begin in the sacral spinal cord?J Neurol. 2019 Nov 12. doi: 10.1007/s00415-019-09597-2.
     
  11. Efthymiou S, Salpietro V, Malintan N, et al.Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination.Brain. 2019 Oct 1;142(10):2948-2964. doi: 10.1093/brain/awz248.
     
  12. Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Halliday G, Höglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W, Wenning GK. Movement Disorder Society Multiple System Atrophy Study Group.A critique of the second consensus criteria for multiple system atrophy. Mov Disord. 2019 Jul;34(7):975-984. doi: 10.1002/mds.27701.
     
  13. Wells R, Elliott AD, Mahajan R, Page A, Iodice V, Sanders P, Lau DH. Efficacy of Therapies for Postural Tachycardia Syndrome: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2018 Aug;93(8):1043-1053.
     
  14. Chelban V, Vichayanrat E, Schottlaende L, Iodice V, Houlden H. Autonomic dysfunction in genetic forms of synucleinopathies. Mov Disord. 2018 Mar;33(3):359-371.
     
  15. Owens AP, Low DA, Iodice V, Critchley HD, Mathias CJ. The genesis and presentation of anxiety in disorders of autonomic overexcitation Auton Neurosci. 2017 Mar;203:81-87.
     
  16. Vichayanrat E, Low DA, Iodice V, Stuebner E, Hagen EM, Mathias CJ. Twenty-four-hour ambulatory blood pressure and heart rate profiles in diagnosing orthostatic hypotension in Parkinson's disease and multiple system atrophy. Eur J Neurol. 2017 Jan;24(1):90-97. doi: 10.1111/ene.13135. Epub 2016 Oct 7.
     
  17. Ponnusamy V, Owens AP, Purkayastha S, Iodice V, Mathias CJ. Orthostatic intolerance and autonomic dysfunction following bariatric surgery: A retrospective study and review of the literature. Auton Neurosci. 2016 Jul;198:1-7.
     
  18. Carr AS, Pelayo AL, Evans MRB, Laura M, Blake J, Stancanelli C, Iodice V, Wechalekar AD, Whelan CJ, Gilmore JD, Hawkins PN, MM Reilly. Neuropathy Phenotype of Transthyretin Amyloidosis (ATTR) in the UK. J Neurol Neurosurg Psychiatry. 2015
     
  19. Ahmed RM, Iodice V, Daveson N, Kiernan MC, Piguet O, Hodges JR5. Autonomic dysregulation in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2014 Dec 30.
     
  20. Iodice V, Sandroni P. Autonomic Neuropathy. Continuum in Neurology 2014
     
  21. Figueroa JJ, Singer W, Parsaik A, Benarroch EE, Ahlskog JE, Fealey RD, Parisi JE, Sandroni P, Mandrekar J, Iodice V, Low PA, Bower JH. Multiple system atrophy: prognostic indicators of survival. Mov Disord. 2014 Aug;29(9)
     
  22. Low DA, Vichayanrat E, Iodice V, Mathias CJ. Exercise hemodynamics in Parkinson's disease and autonomic dysfunction. Parkinsonism Relat Disord. 2014 May
     
  23. Vichayanrat E, Low DA, Asahina M, Owens AP, Iodice V, Galizia G, Mathias CJ. L-DOPS and the treatment of neurogenic orthostatic hypotension. Future Neurology. 2013 8:4, 381-397.
     
  24. Idiaquez J, Fadic R, Verdugo R, Idiaquez JF, Iodice V, Low DA, Mathias CJ, Lombardi R, Lauria G. Pure autonomic failure with cold induced sweating. Auton Neurosci. 2013 Mar 16.
     
  25. Mathias CJ, Iodice V, Low D. Autonomic dysfunction: recognition, diagnosis, investigation, management, and autonomic neurorehabilitation. Handb Clin Neurol. 2013;110:239-53.
     
  26. Asahina M, Vichayanrat E, Low DA, Iodice V, Mathias CJ Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology. J Neurol Neurosurg Psychiatry. 2012 Oct 15.
     
  27. Kimpinski K, Figueroa JJ, Singer W, Sletten DM, Iodice V, Sandroni P, Fischer PR, Opfer-Gehrking TL, Gehrking JA, Low PA. A Prospective, 1-Year Follow-up Study of Postural Tachycardia Syndrome. Mayo Clin Proc. 2012 Aug;87(8):746-52. Epub 2012 Jul 15.
     
  28. Kimpinski K, Iodice V, Burton DD, Camilleri M, Mullan BP, Lipp A, Sandroni P, Gehrking TL, Sletten DM, Ahlskog JE, Fealey RD, Singer W, Low PA. The role of autonomic testing in the differentiation of Parkinson's disease from multiple system atrophy. J Neurol Sci. 2012 Jun 15;317(1-2):92-6.
     
  29. Iodice V., Lipp A., Ahlskog J. E., Sandroni P., Fealey R. D., Parisi J. E., Matsumoto J. Y., Benarroch E. E., Kimpinski K., Singer W., Gehrking T. L. Gehrking J.A, Sletten D.M., Schmeichel A.M., Bower H.J., Sid Gilman, Figueroa J., and Low P.A. Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests. J Neurol Neurosurg Psychiatry. 2012 Jan 6.
     
  30. Mathias CJ, Low DA, Iodice V, Owens A, Kirbiš M, Grahame R. The Postural Tachycardia Syndrome (PoTS) – Current experiences and concepts. Nat Rev Neurol. 2011 Dec 6;8(1):22-34
     
  31. Berganzo K, Tijero B, Somme JH, Llorens V, Sánchez-Manso JC, Low D, Iodice V, Vichayanrat E, Mathias CJ, Lezcano E, Zarranz JJ, Gómez-Esteban JC. SCOPA-AUT scale in different parkinsonisms and its correlation with (123) I-MIBG cardiac scintigraphy. Parkinsonism Relat Disord. 2011 Sep 9.
     
  32. Iodice V., Low D.A., Vichayanrat E., Mathias C.J. Cardiovascular Autonomic Dysfunction in MSA and Parkinson’s Disease: Similarities and Differences. J Neurol Sci. 2011 Nov 15;310(1-2):133-8. 10
     
  33. K. Kimpinski, J.J. Figueroa, D.M. Sletten, V. Iodice, W. Singer, P. Sandroni, TL Opfer-Gehrking, JA Gehrking and P. A. Low. A prospective one year follow up study of postural tachycardia syndrome. Mayo Clin Proc. 2012 Aug;87(8):746-52.
     
  34. K Kimpinski , V. IodiceP. SandroniR. FealeyS. VerninoP. A. Low Sudomotor dysfunction in autoimmune autonomic ganglionopathy: a follow-up study. Clin Auton Res 2012 Jun;22(3):131-6
     
  35. Perretti A, De Rosa A, Marcantonio L, Iodice V, Estraneo A, Manganelli F, Garavaglia B, Filla A, Santoro L, De Michele G. Neurophysiological evaluation of motor corticospinal pathways by TMS in idiopathic early-onset Parkinson's disease. Clin Neurophysiol. 2010 Aug 24.
     
  36. Dyck PJ, Overland CJ, Low PA, Litchy WJ, Davies JL, Dyck PJ, O'Brien PC; Cl vs. NPhys Trial Investigators, Albers JW, Andersen H, Bolton CF, England JD, Klein CJ, Llewelyn JG, Mauermann ML, Russell JW, Singer W, Smith AG, Tesfaye S, Vella A. Collaborators (20) Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial. Muscle Nerve. 2010 Aug;42(2):157-64.
     
  37. Kimpinski K, Iodice V, Low PA. Postural Tachycardia Syndrome associated with peripartum cardiomyopathy. Auton Neurosci. 2010 Feb 16.
     
  38. Kimpinski K, Iodice V, Sandroni P, Fealey RD, Vernino S, Low PA. Sudomotor dysfunction in autoimmune autonomic ganglionopathy. Neurology. 2009 Nov 3;73(18):1501-6.
     
  39. Iodice V, Vernino, S, Kimpinski, K, Sandroni, P, Fealey, RD, Low, PA. (2009) Autoimmune Autonomic Ganglionopathy: Response to Immunomodulatory Therapy. In: Dyck, P.J. Companion to Peripheral Neuropathy. USA: Elsevier.
     
  40. Kimpinski K, Iodice V, Vernino S, Sandroni P, Low PA. (2009) Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy. Autonom. Neurosci 2009 Jun 19.
  41. Iodice V, Kimpinski K, Vernino S, Sandroni P, Fealey RD and Low PA. Immunotherapy for Autoimmune Autonomic Ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):22-5.
     
  42. Iodice V, Kimpinski K, Vernino S, Sandroni P, Fealey RD, and Low PA. Efficacy of immunotherapy in autonomic autoimmune ganglionopathy. Neurology. 2009 Jun 9;72(23):2002-8.
     
  43. Lipp A, Sandroni P, Ahlskog EJ, Fealey RD, Kimpinski K, Iodice V, Gehrking TL, Weigand SD, Sletten DM, Gehrking JA, Nickander KK, Singer W, Maraganore DM, Gilman S, Wenning GK, Shults CM and Low PA. Prospective Differentiation of Multiple System Atrophy from Parkinson's Disease, with and without Autonomic Failure. Arch Neurol. 2009 Jun;66(6):742-50.
     
  44. Manganelli F, Ragno M, Cacchiò G, Iodice V, Trojano L, Silvaggio F, Scarcella M, Grazioli M, Santoro L, Perretti A. Motor cortex cholinergic dysfunction in CADASIL: a transcranial magnetic demonstration. Clin Neurophysiol. 2008 Feb;119(2):351-5. Epub 2007 Dec 11.
     
  45. Manganelli F, Iodice V, Provitera V, Pisciotta C, Nolano M, Perretti A, Santoro L. Small-fiber involvement in spinobulbar muscular atrophy (Kennedy's disease). Muscle Nerve. 2007 Dec; 36(6):816-20.
     
  46. Quarantelli M, Lanzillo R, Del Vecchio W, Mollica C, Prinster A, Iadicicco L, Iodice V, Santoro L, Salvatore M. Modifications of brain tissue volumes in facioscapulohumeral dystrophy. Neuroimage. 2006 Jun 26