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Professor Bryan Williams

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

2827942

Professional background

Professor Bryan Williams is a chair of medicine at University College London (UCL) and a consultant physician at UCLH with a special interest in hypertension. He is also Chief Scientific and Chief Medical Officer at the British Heart Foundation.

From 2012 to 2023, he served as the director of the NIHR UCLH Biomedical Research Centre and held the position of director of research at UCLH from 2014 to 2023.

In the 2024 New Years Honours list he was awarded an OBE for services to medicine.

Professor Williams research and clinical practice is in the field of high blood pressure (hypertension) in which he is recognised as one of the world's leading authorities. He has a particular interest in complex and difficult to control blood pressure and high blood pressure in younger people. He is past-chairman of the European Council on Hypertension of the European Society of Cardiology (2016 – 2018) and past-president of the British Hypertension Society (2001-2003).

He was chairman of the NICE Hypertension Guidelines Development Group (2011), chairman of the NICE Hypertension National Quality Standards development group (2013) and chairman of the NICE Evidence Update for Hypertension report (2013). He was also chairman of the European Guidelines for the management of high blood pressure (2018).

Professor Williams was also chairman and is clinical lead for the Royal College of Physicians London team that led the development of the National early Warning Score (NEWS and NEWS2) which has been widely implemented to improve patient safety in the NHS. He is a member of national and international hypertension societies and a fellow of the American Heart Association, the European Society of Cardiology and the Royal College of Physicians, London.

Specialties

Research interests

  • High blood pressure
  • Cardiovascular disease
  • Development of new treatments and methods for patient monitoring. 

Publications

Recent publications:

  • Böhm, M., Schumacher, H., Teo, K. K., Lonn, E. M., Mahfoud, F., Mann, J. F. E., . . . Yusuf, S. (2017). Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Lancet (London, England). doi:10.1016/s0140-6736(17)30754-7
  • Williams, B., Cockcroft, J. R., Kario, K., Zappe, D. H., Brunel, P. C., Wang, Q., & Guo, W. (2017). Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension: The PARAMETER Study. Hypertension. doi:10.1161/HYPERTENSIONAHA.116.08556
  • Williams, B., & Stone, G. (2017). INTRODUCTION OF THE CALM II STUDY: A MULTI-CENTER, BLINDED, SHAM-CONTROLLED PIVOTAL TRIAL OF AN ENDOVASCULAR CAROTID BAROSTIMULATION IMPLANT FOR THE TREATMENT OF RESISTANT HYPERTENSION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69 (11), 1726. ELSEVIER SCIENCE INC.
  • Linz, D., Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L., Schlaich, M., . . . Global SYMPLICITY Registry Investigators. (2017). Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: results from the Global SYMPLICITY Registry. Journal of Hypertension, 35 (1), 148-153. doi:10.1097/HJH.0000000000001142
  • Gupta, P., Patel, P., Štrauch, B., Lai, F. Y., Akbarov, A., Marešová, V., . . . Tomaszewski, M. (2017). Risk Factors for Nonadherence to Antihypertensive Treatment. Hypertension (Dallas, Tex. : 1979). doi:10.1161/hypertensionaha.116.08729
  • Atkins, E. R., Hirakawa, Y., Salam, A., Woodward, M., Cooper, M., Hamet, P., . . . Rodgers, A. (2017). Side effects and tolerability of combination blood pressure lowering according to blood pressure levels: an analysis of the perindopril protection against recurrent stroke study and action in diabetes and vascular disease: preterax and diamicron-MR controlled evaluation trials. Journal of hypertension. doi:10.1097/hjh.0000000000001287
  • Blomster, J. I., Zoungas, S., Woodward, M., Neal, B., Harrap, S., Poulter, N., . . . Hillis, G. S. (2017). The impact of level of education on vascular events and mortality in patients with type 2 diabetes mellitus: Results from the ADVANCE study. Diabetes Research and Clinical Practice, 127, 212-217. doi:10.1016/j.diabres.2017.03.015
  • Denham, J., Brown, N. J., Tomaszewski, M., Williams, B., O Brien, B. J., & Charchar, F. J. (2016). Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness. European Journal of Applied Physiology, 1-8. doi:10.1007/s00421-016-3407-x
  • Williams, B., Brunel, P., Lacy, P. S., Baschiera, F., Zappe, D. H., Kario, K., & Cockcroft, J. (2016). Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value. Artery Research, 17, 1-15. doi:10.1016/j.artres.2016.10.154
  • Banegas, J. R., Ruilope, L. M., de la Sierra, A., Vinyoles, E., Gorostidi, M., de la Cruz, J. J., . . . Williams, B. (2016). Clinic Versus Daytime Ambulatory Blood Pressure Difference in Hypertensive Patients: The Impact of Age and Clinic Blood Pressure. Hypertension. doi:10.1161/HYPERTENSIONAHA.116.08567
  • Williams, B. (2016). Drug discovery in renin-angiotensin system intervention: Past and future. Therapeutic Advances in Cardiovascular Disease, 10 (3), 118-125. doi:10.1177/1753944716642680
  • Brown, M. J., Williams, B., Morant, S. V., Webb, D. J., Caulfield, M. J., Cruickshank, J. K., . . . MacDonald, T. M. (2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. LANCET DIABETES & ENDOCRINOLOGY, 4 (2), 136-147. doi:10.1016/S2213-8587(15)00377-0
  • Gupta, P., Patel, P., Horne, R., Buchanan, H., Williams, B., & Tomaszewski, M. (2016). How to Screen for Non-Adherence to Antihypertensive Therapy. CURRENT HYPERTENSION REPORTS, 18 (12), ARTN 89. doi:10.1007/s11906-016-0697-7
  • Wong, M. G., Perkovic, V., Chalmers, J., Woodward, M., Li, Q., Cooper, M. E., . . . Zoungas, S. (2016). Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON. Diabetes care, 39 (5), 694-700.
  • Mohammedi, K., Woodward, M., Hirakawa, Y., Zoungas, S., Williams, B., Lisheng, L., . . . Chalmers, J. (2016). Microvascular and Macrovascular Disease and Risk for Major Peripheral Arterial Disease in Patients With Type 2 Diabetes. Diabetes care.
  • Williams, B., MacDonald, T. M., Morant, S. V., & Brown, M. J. (2016). PATHWAY-2: spironolactone for resistant hypertension Reply. LANCET, 387 (10026), 1373-1374.
  • Jones, A., Pruessner, J. C., McMillan, M. R., Jones, R. W., Kowalik, G. T., Steeden, J. A., . . . Muthurangu, V. (2016). Physiological adaptations to chronic stress in healthy humans – why might the sexes have evolved different energy utilisation strategies?. Journal of Physiology, 594 (15), 4297-4307. doi:10.1113/JP272021
  • Alshehry, Z. H., Mundra, P. A., Barlow, C. K., Mellett, N. A., Wong, G., McConville, M. J., . . . Meikle, P. J. (2016). Plasma Lipidomic Profiles Improve Upon Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes. Circulation. doi:10.1161/CIRCULATIONAHA.116.023233
  • Newman, J. E., Bown, M. J., Sayers, R. D., Thompson, J. P., Robinson, T. G., Williams, B., . . . Naylor, A. R. (2016). Post-Carotid Endarterectomy Hypertension. Part 1: Association with Pre-operative Clinical, Imaging, and Physiological Parameters. European Journal of Vascular and Endovascular Surgery. doi:10.1016/j.ejvs.2017.01.013
  • Sheppard, J. P., Stevens, R., Gill, P., Martin, U., Godwin, M., Hanley, J., . . . McManus, R. J. (2016). Predicting out-of-office blood pressure in the clinic (PROOF-BP): Derivation and validation of a tool to improve the accuracy of blood pressure measurement in clinical practice. Hypertension, 67 (5), 941-950. doi:10.1161/HYPERTENSIONAHA.115.07108
  • Hosford, P. S., Christie, I. N., Wells, J., Turlejski, T., Millar, J., Ramage, A. G., . . . Marina, N. (2016). Regional differences of activity-dependent changes in brain oxygenation in subjects with arterial hypertension. Presented at: Congress of the European-Society-of-Cardiology (ESC).
  • Böhm, M., Ukena, C., Ewen, S., Linz, D., Zivanovic, I., Hoppe, U., . . . Global SYMPLICITY Registry Investigators. (2016). Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension: 12-month outcomes from the global SYMPLICITY registry. J Hypertens. doi:10.1097/HJH.0000000000001085
  • Hirakawa, Y., Arima, H., Webster, R., Zoungas, S., Li, Q., Harrap, S., . . . Chalmers, J. (2016). Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes. JOURNAL OF HYPERTENSION, 34 (4), 781-787. doi:10.1097/HJH.0000000000000841
  • Patel, P., Gupta, P. K., White, C. M., Stanley, A. G., Williams, B., & Tomaszewski, M. (2016). Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation. Journal of human hypertension, 30 (6), 368-373.
  • Williams, B. (2016). Time to Abandon Clinic Blood Pressure for the Diagnosis of Hypertension?. CIRCULATION, 134 (23), 1808-1811. doi:10.1161/CIRCULATIONAHA.116.023914
  • Williams, B. (2016). Vascular ageing and interventions: Lessons and learnings. Therapeutic Advances in Cardiovascular Disease, 10 (3), 126-132. doi:10.1177/1753944716642681
  • Schwartz, C., Seyed-Safi, A., Sayeed Haque, M., Bray, E., Greenfield, S., Hobbs, R., . . . McManus, R. (2016). [OP.6C.03] DO PATIENTS ACTUALLY DO WHAT WE ASK? PATIENT PERFORMANCE AND PERSISTENCE IN THE TASMIN-SR BLOOD PRESSURE SELF-MANAGEMENT TRIAL. Journal of Hypertension, 34 Suppl 2, e72. doi:10.1097/01.hjh.0000491525.34594.dc
  • Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L. M., Schlaich, M. P., Schmieder, R. E., . . . Böhm, M. (2015). 4A.01: LONG-TERM EFFECTS OF RENAL ARTERY DENERVATION IN REAL WORLD PATIENTS WITH UNCONTROLLED HYPERTENSION FROM THE GLOBAL SYMPLICITY REGISTRY. Journal of hypertension, 33 Suppl 1, e49-?. doi:10.1097/01.hjh.0000467475.67073.7e
  • Mahfoud, F., Linz, D., Mancia, G., Narkiewicz, K., Ruilope, L. M., Schlaich, M. P., . . . Böhm, M. (2015). 8B.04: RENAL ARTERY DENERVATION FOR TREATMENT OF HYPERTENSIVE PATIENTS WITH OR WITHOUT OBSTRUCTIVE SLEEP APNEA AND RESISTANT HYPERTENSION: RESULTS FROM THE GLOBAL SYMPLICITY REGISTRY. Journal of hypertension, 33 Suppl 1, e108-?. doi:10.1097/01.hjh.0000467640.39623.b2
  • Brown, M. J., Williams, B., MacDonald, T. M., Caulfield, M., Cruickshank, J. K., McInnes, G., . . . Ford, I. (2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. BMJ open, 5 (8), e008086-?. doi:10.1136/bmjopen-2015-008086
  • Lacy, P. S., Brunel, P., Bader, G., Jones, A., Baschiera, F., Düsing, R., & Williams, B. (2015). Effects of treatment withdrawal on brachial and central aortic pressure after direct renin inhibition or angiotensin receptor blockade. Journal of the renin-angiotensin-aldosterone system : JRAAS. doi:10.1177/1470320315579592
  • Hudson, L. D., Viner, R. M., Rapala, A., Khan, T., & Williams, B. (2015). Evidence for contemporary arterial stiffening in obese children and adolescents using pulse wave velocity: A systematic review and meta-analysis. Atherosclerosis, 241 (2), 376-386. doi:10.1016/j.atherosclerosis.2015.05.014
  • Böhm, M., Mahfoud, F., Ukena, C., Hoppe, U. C., Narkiewicz, K., Negoita, M., . . . Mancia, G. (2015). First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension. Hypertension, 65 (4), 766-774. doi:10.1161/HYPERTENSIONAHA.114.05010
  • Lobo, M. D., de Belder, M. A., Cleveland, T., Collier, D., Dasgupta, I., Deanfield, J., . . . Renal Association. (2015). Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. Heart, 101 (1), 10-16. doi:10.1136/heartjnl-2014-307029
  • MacDonald, T. M., Williams, B., Caulfield, M., Cruickshank, J. K., McInnes, G., Sever, P., . . . Brown, M. J. (2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. BMJ open, 5 (8), e007645-?. doi:10.1136/bmjopen-2015-007645
  • Bray, E. P., Jones, M. I., Banting, M., Greenfield, S., Hobbs, F. D., Little, P., . . . Mcmanus, R. J. (2015). Performance and persistence of a blood pressure self-management intervention: telemonitoring and self-management in hypertension (TASMINH2) trial. J Hum Hypertens, 29 (7), 436-441. doi:10.1038/jhh.2014.108
  • Williams, B., MacDonald, T. M., Caulfield, M., Cruickshank, J. K., McInnes, G., Sever, P., . . . Brown, M. J. (2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. BMJ open, 5 (8), e008951-?. doi:10.1136/bmjopen-2015-008951
  • Thomas, M. C., Woodward, M., Neal, B., Li, Q., Pickering, R., Marre, M., . . . Hillis, G. S. (2015). The Relationship Between Levels of Advanced Glycation End-Products and Their Soluble Receptor and Adverse Outcomes in Adults With Type 2 Diabetes. Diabetes care.
  • Williams, B. (2015). Treating hypertension in patients with diabetes: When to start and how low to go?. JAMA - Journal of the American Medical Association, 313 (6), 573-574.
  • Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Shah, A. D., Denaxas, S., . . . Hemingway, H. (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet, 383 (9932), 1899-1911. doi:10.1016/S0140-6736(14)60685-1
  • Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Denaxas, S., Shah, A. D., . . . Hemingway, H. (2014). Blood pressure and incidence of twelve cardiovascular diseases; lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. EUROPEAN HEART JOURNAL, 35, 1082.
  • Welsh, P., Woodward, M., Hillis, G. S., Li, Q., Marre, M., Williams, B., . . . Sattar, N. (2014). Do cardiac biomarkers NT-proBNP and hsTnT predict microvascular events in patients with type 2 diabetes? Results from the ADVANCE trial. Diabetes Care, 37 (8), 2202-2210. doi:10.2337/dc13-2625
  • McManus, R. J., Mant, J., Haque, M. S., Bray, E. P., Bryan, S., Greenfield, S. M., . . . Buckley, D. (2014). Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: the TASMIN-SR randomized clinical trial. JAMA, 312 (8), 799-808. doi:10.1001/jama.2014.10057
  • Chalmers, J., Arima, H., Woodward, M., Zoungas, S., Patel, A., Hirakawa, Y., . . . Harrap, S. (2014). Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: Results from the action in diabetes and vascular disease: Preterax and diamicron controlled evaluation (ADVANCE) trial. Hypertension, 63 (2), 259-264. doi:10.1161/HYPERTENSIONAHA.113.02252
  • Lacy, P. S., Brunel, P., Baschiera, F., Botha, J., & Williams, B. (2014). Effects of exercise on central aortic pressure before and after treatment with renin-angiotensin system blockade in patients with hypertension. J Renin Angiotensin Aldosterone Syst. doi:10.1177/1470320314538879
  • van Dieren, S., Kengne, A. P., Chalmers, J., Beulens, J. W. J., Davis, T. M. E., Fulcher, G., . . . Zoungas, S. (2014). Efficacy and safety of teneligliptin added to glimepiride in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study with an open-label, long-term extension. DIABETES OBESITY & METABOLISM, 16 (5), 426-432. doi:10.1111/dom.12235
  • Davies, J. E., Lacy, P., Tillin, T., Collier, D., Cruickshank, J. K., Francis, D. P., . . . Hughes, A. D. (2014). Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial. Hypertension, 64 (1), 60-68. doi:10.1161/HYPERTENSIONAHA.113.02838
  • Zoungas, S., Chalmers, J., Neal, B., Billot, L., Li, Q., Hirakawa, Y., . . . Biostat, M. (2014). Follow-up of blood-pressure lowering and glucose control in type 2 diabetes. New England Journal of Medicine, 371 (15), 1392-1406. doi:10.1056/NEJMoa1407963
  • Banegas, J. R., Ruilope, L. M., de la Sierra, A., de la Cruz, J. J., Gorostidi, M., Segura, J., . . . Williams, B. (2014). High prevalence of masked uncontrolled hypertension in people with treated hypertension. Eur Heart J, 35 (46), 3304-3312. doi:10.1093/eurheartj/ehu016
  • Tomaszewski, M., White, C., Patel, P., Masca, N., Damani, R., Hepworth, J., . . . Williams, B. (2014). High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis. Heart, 100 (11), 855-861. doi:10.1136/heartjnl-2013-305063
  • Hodgkinson, J., Grant, S., Bray, E., Stevens, S., Martin, U., Perera-Salazar, R., . . . McManus, R. (2014). Home Blood Pressure Monitoring - what is the optimal schedule? A systematic review. JOURNAL OF HUMAN HYPERTENSION, 28 (10), 633-634.
  • Zoungas, S., Woodward, M., Li, Q., Cooper, M. E., Hamet, P., Harrap, S., . . . Grp, A. D. V. A. N. C. E. C. (2014). Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes. DIABETOLOGIA, 57 (12), 2465-2474. doi:10.1007/s00125-014-3369-7
  • Zoungas, S., Woodward, M., Li, Q., Patel, A., Chalmers, J., Cooper, M. E., . . . Williams, B. (2014). Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes. Diabetologia, 57 (12), 2465-2474. doi:10.1007/s00125-014-3369-7
  • van Dieren, S., Kengne, A. P., Chalmers, J., Patel, A., Neal, B., Woodward, M., . . . Williams, B. (2014). Intensification of medication and glycaemic control among patients with type 2 diabetes-The ADVANCE trial. Diabetes, Obesity and Metabolism, 16 (5), 426-432. doi:10.1111/dom.12238
  • Sheppard, J. P., Holder, R., Nichols, L., Bray, E., Hobbs, F. D., Mant, J., . . . McManus, R. J. (2014). Predicting out-of-office blood pressure level using repeated measurements in the clinic: an observational cohort study. J Hypertens, 32 (11), 2171-2178. doi:10.1097/HJH.0000000000000319
  • Williams, B., Cockcroft, J. R., Kario, K., Zappe, D. H., Cardenas, P., Hester, A., . . . Zhang, J. (2014). Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. BMJ Open, 4 (2), e004254-?. doi:10.1136/bmjopen-2013-004254
  • Kaambwa, B., Bryan, S., Jowett, S., Mant, J., Bray, E. P., Hobbs, F. D., . . . McManus, R. J. (2014). Telemonitoring and self-management in the control of hypertension (TASMINH2): a cost-effectiveness analysis. Eur J Prev Cardiol, 21 (12), 1517-1530. doi:10.1177/2047487313501886
  • Blomster, J. I., Zoungas, S., Chalmers, J., Li, Q., Chow, C. K., Woodward, M., . . . Hillis, G. S. (2014). The Relationship Between Alcohol Consumption and Vascular Complications and Mortality in Individuals With Type 2 Diabetes. DIABETES CARE, 37 (5), 1353-1359. doi:10.2337/dc13-2727
  • Hillis, G. S., Welsh, P., Chalmers, J., Perkovic, V., Chow, C. K., Li, Q., . . . Woodward, M. (2014). The Relative and Combined Ability of High-Sensitivity Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Predict Cardiovascular Events and Death in Patients With Type 2 Diabetes. DIABETES CARE, 37 (1), 295-303. doi:10.2337/dc13-1165
  • Kjeldsen, S., Feldman, R. D., Lisheng, L., Mourad, J. -. J., Chiang, C. -. E., Zhang, W., . . . Williams, B. (2014). Updated National and International Hypertension Guidelines: A Review of Current Recommendations. DRUGS, 74 (17), 2033-2051. doi:10.1007/s40265-014-0306-5
  • Theilade, S., Lajer, M., Hansen, T. W., Joergensen, C., Persson, F., Andrésdottir, G., . . . Williams, B. (2013). 24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study. Cardiovascular Diabetology, 12 (1). doi:10.1186/1475-2840-12-122
  • Williams, B. (2013). Blood pressure and diabetes: a fatal attraction. Eur Heart J, 34 (44), 3395-3397. doi:10.1093/eurheartj/eht365
  • Williams, B., Baschiera, F., Lacy, P. S., Botha, J., Prescott, M. F., & Brunel, P. (2013). Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise. J Renin Angiotensin Aldosterone Syst, 14 (1), 56-66. doi:10.1177/1470320312454766
  • Wong, M. G., Yaghobian Azari, D., Pollock, C. A., Perkovic, V., Woodward, M., Chalmers, J., . . . Cooper, M. (2013). Circulating bone morphogenetic protein-7 and transforming growth factor-β1 are better predictors of renal end points in patients with type 2 diabetes mellitus. Kidney International, 83 (2), 278-284. doi:10.1038/ki.2012.383
  • Mahfoud, F., Mancia, G., Schlaich, M. P., Narkiewicz, K., Ruilope, L., Williams, B., . . . Bohm, M. (2013). Clinical and Procedural Outcomes of Renal Artery Denervation In Real World Patients with Hypertension: An Update From the Global SYMPLICITY Registry. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62 (18), B19-B20.
  • Komori, T., Eguchi, K., Hoshide, S., Williams, B., & Kario, K. (2013). Comparison of wrist-type and arm-type 24-h blood pressure monitoring devices for ambulatory use. Blood Press Monit, 18 (1), 57-62. doi:10.1097/MBP.0b013e32835d124f
  • Nicholls, S. J., Kataoka, Y., Bakris, G. L., Kastelein, J. J. P., Menon, V., Nissen, S. E., . . . Fang, H. (2013). Effect of aliskiren on progression of coronary disease in patients with prehypertension: The AQUARIUS randomized clinical trial. JAMA - Journal of the American Medical Association, 310 (11), 1135-1144. doi:10.1001/jama.2013.277169
  • Hata, J., Arima, H., Rothwell, P. M., Woodward, M., Zoungas, S., Anderson, C., . . . ADVANCE Collaborative Group. (2013). Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial. Circulation, 128 (12), 1325-1334. doi:10.1161/CIRCULATIONAHA.113.002717
  • Mahfoud, F., Böhm, M., Lüscher, T. F., Andersson, B., Baumgartner, I., Cifkova, R., . . . Zeller, T. (2013). Expert consensus document from the European Society of Cardiology on catheter-based renal denervation. European Heart Journal, 34 (28), 2149-2157. doi:10.1093/eurheartj/eht154
  • Hillis, G. S., Welsh, P., Chalmers, J., Chow, C. K., Perkovic, V., Poulter, N., . . . Woodward, M. (2013). High sensitivity cardiac troponin T and N-terminal pro-BNP predict cardiovascular events and death in patients with type 2 diabetes mellitus. EUROPEAN HEART JOURNAL, 34, 301.
  • Tomaszewski, M., Williams, B., & Musameh, M. D. (2013). Hypertension - A clinical update for physicians. Clinical Medicine, Journal of the Royal College of Physicians of London, 13 (2), 182-184. doi:10.7861/clinmedicine.13-2-182
  • Musameh, M. D., Tomaszewski, M., & Williams, B. (2013). Hypertension - a clinical update for physicians. Clin Med, 13 (2), 182-184. doi:10.7861/clinmedicine.13-2-182
  • van Dieren, S., Kengne, A. P., Chalmers, J., Patel, A., Neal, B., Woodward, M., . . . Williams, B. (2013). Intensification of medication and glycaemic control among patients with type 2 diabetes - the ADVANCE trial. Diabetes, Obesity and Metabolism. doi:10.1111/dom.12238
  • Schlaich, M. P., Hering, D., Esler, M. D., Schmieder, R. E., Bakris, G., Blankestijn, P. J., . . . Zeller, T. (2013). International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension. Journal of the American College of Cardiology, 62 (22), 2031-2045. doi:10.1016/j.jacc.2013.08.1616
  • Williams, B., Lacy, P. S., Baschiera, F., Brunel, P., & Düsing, R. (2013). Novel description of the 24-hour circadian rhythms of brachial versus central aortic blood pressure and the impact of blood pressure treatment in a randomized controlled clinical trial: The Ambulatory Central Aortic Pressure (AmCAP) Study. Hypertension, 61 (6), 1168-1176. doi:10.1161/HYPERTENSIONAHA.111.00763
  • Jones, M. I., Holder, R., McManus, R. J., Little, P., Mant, J., Williams, B., . . . Hobbs, F. D. R. (2013). Patient self-monitoring of blood pressure and self-titration of medication in primary care: The TASMINH2 trial qualitative study of health professionals' experiences. British Journal of General Practice, 63 (611). doi:10.3399/bjgp13X668168
  • Newman, J. E., Bown, M. J., Sayers, R. D., Thompson, J. P., Robinson, T. G., Williams, B., . . . Naylor, A. R. (2013). Poorly controlled BP and impaired baroreceptor function (but not impaired autoregulation) are associated with a significantly higher prevalence of post-carotid endarterectomy hypertension. BRITISH JOURNAL OF SURGERY, 100, 12.
  • Böhm, M., Mahfoud, F., Ukena, C., Bauer, A., Fleck, E., Hoppe, U. C., . . . Mancia, G. (2013). Rationale and design of a large registry on renal denervation: The Global SYMPLICITY registry. EuroIntervention, 9 (4), 484-492. doi:10.4244/EIJV9I4A78
  • Myat, A., Redwood, S. R., Qureshi, A. C., Thackray, S., Cleland, J. G. F., Bhatt, D. L., . . . Gersh, B. J. (2013). Renal sympathetic denervation therapy for resistant hypertension a contemporary synopsis and future implications. Circulation: Cardiovascular Interventions, 6 (2), 184-197. doi:10.1161/CIRCINTERVENTIONS.112.000037
  • McManus, R. J., Mant, J., Haque, M. S., Bray, E. P., Greenfield, S., Jones, M. I., . . . Hobbs, F. D. R. (2013). Targets and self-management for the control of blood pressure in stroke and at risk groups (TASMIN-SR): a randomised controlled trial. JOURNAL OF HUMAN HYPERTENSION, 27 (10), 643.
  • O'Brien, C., Bray, E. P., Greenfield, S. M., Haque, M. S., Jones, M. I., Schwartz, C., . . . Williams, B. (2013). Targets and self-management for the control of blood pressure in stroke and at risk groups (TASMIN-SR): Protocol for a randomised controlled trial. BMC Cardiovascular Disorders, 13. doi:10.1186/1471-2261-13-21
  • Boehm, M., Schlaich, M., Narkiewicz, K., Ruilope, L., Williams, B., Schmieder, R., . . . Mancia, G. (2013). The blood pressure lowering effects of renal denervation in a real world population of patients with uncontrolled hypertension: early outcomes from the Global SYMPLICITY registry. EUROPEAN HEART JOURNAL, 34, 673-674.
  • Lajer, M., Theilade, S., Joergensen, C., Persson, F., Andresdottir, G., Nielsen, S., . . . Rossing, P. (2012). Bone mineral density, kidney function and arterial stiffness in long-standing type 1 diabetic patients with or without diabetic nephropathy. DIABETOLOGIA, 55, S467-S468.
  • Williams, B., & Lacy, P. S. (2012). Central aortic pressure: The next frontier in blood pressure measurement?. Special Issues in Hypertension, 181-197. doi:10.1007/978-88-470-2601-8_15
  • Webb, D. R., Khunti, K., Lacy, P., Gray, L. J., Mostafa, S., Talbot, D., . . . Davies, M. J. (2012). Conduit vessel stiffness in British south Asians of Indian descent relates to 25-hydroxyvitamin D status. J Hypertens, 30 (8), 1588-1596. doi:10.1097/HJH.0b013e328354f385
  • McManus, R. J., Heneghan, C., Hobbs, F. R., Lovibond, K., & Williams, B. (2012). Cost-effectiveness of diagnosis of high blood pressure in primary care - Authors' reply. The Lancet, 379 (9817), 710. doi:10.1016/S0140-6736(12)60303-1
  • Williams, B. (2012). Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity-mortality. JOURNAL OF HYPERTENSION, 30, S13-S18. doi:10.1097/HJH.0b013e328353e523
  • Theilade, S., Lajer, M., Joergensen, C., Persson, F., Andresdottir, G., Reinhard, H., . . . Rossing, P. (2012). First ever 24-hour central blood pressure in patients with type 1 diabetes. DIABETOLOGIA, 55, S504.
  • McManus, R., Caulfield, M., & Williams, B. (2012). NICE hypertension guideline 2011: Evidence based evolution. BMJ (Online), 344 (7841). doi:10.1136/bmj.e181
  • Jones, M. I., Greenfield, S. M., Bray, E. P., Baral-Grant, S., Holder, R., Virdee, S. K., . . . Williams, B. (2012). Patients' experiences of self-monitoring blood pressure and self-titration ofmedication: The TASMINH2 trial qualitative study. British Journal of General Practice, 62 (595). doi:10.3399/bjgp12X625201
  • Brown, M., Caulfield, M., Cruickshank, K., MacDonald, T., McInnes, G., Sever, P., . . . Ford, I. (2012). Proportion of patients with previously uncontrolled hypertension who achieve target blood pressure through participation in the BHS's prevention and treatment of hypertension with algorithm based therapy (PATHWAY) trials. JOURNAL OF HUMAN HYPERTENSION, 26 (10), 625.
  • Myat, A., Redwood, S. R., Qureshi, A. C., Spertus Director, J. A., & Williams, B. (2012). Resistant hypertension. BMJ (Online), 345 (7884). doi:10.1136/bmj.e7473
  • Hillis, G. S., Hata, J., Woodward, M., Perkovic, V., Arima, H., Chow, C. K., . . . Chalmers, J. (2012). Resting Heart Rate and the Risk of Microvascular Complications in Patients With Type 2 Diabetes Mellitus. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 1 (5), UNSP e002832. doi:10.1161/JAHA.112.002832
  • Redon, J., Mancia, G., Sleight, P., Williams, B., Schumacher, H., Böhm, M., . . . Yusoff, K. (2012). Safety and efficacy of low blood pressures among patients with diabetes: Subgroup analyses from the ontarget (ongoing telmisartan alone and in combination with ramipril global endpoint trial). Journal of the American College of Cardiology, 59 (1), 74-83. doi:10.1016/j.jacc.2011.09.040
  • Tomaszewski, M., Williams, B., & Samani, N. J. (2012). The John Swales Lecture: a new initiative to honour the founding editor of the Journal of Hypertension. J Hypertens, 30 (11), 2059-?. doi:10.1097/HJH.0b013e328357f1ac
  • Wong, G., Craig, J. C., Howard, K., Chapman, J. R., Zoungas, S., Lo, S., . . . Williams, B. (2012). The risk of cancer in people with diabetes and chronic kidney disease. Nephrology Dialysis Transplantation, 27 (8), 3337-3344. doi:10.1093/ndt/gfs022
  • Parthasarathy, H. K., Ménard, J., White, W. B., Young, W. F., Williams, G. H., Williams, B., . . . MacDonald, T. M. (2011). A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism. Journal of Hypertension, 29 (5), 980-990. doi:10.1097/HJH.0b013e3283455ca5
  • Williams, B., Krause, T., Lovibond, K., Caulfield, M., & McCormack, T. (2011). Authors' reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. BMJ (Online), 343 (7827). doi:10.1136/bmj.d6506
  • Lovibond, K., Wonderling, D., Jowett, S., Barton, P., Hodgkinson, J., McManus, R. J., . . . Williams, B. (2011). Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: A modelling study. The Lancet, 378 (9798), 1219-1230. doi:10.1016/S0140-6736(11)61184-7
  • Williams, B., Lacy, P. S., Yan, P., Hwee, C. N., Liang, C., & Ting, C. M. (2011). Development and validation of a novel method to derive central aortic systolic pressure from the radial pressure waveform using an n-point moving average method. J Am Coll Cardiol, 57 (8), 951-961. doi:10.1016/j.jacc.2010.09.054
  • Williams, B., Baschiera, F., Lacy, P. S., Papst, C. C., & Brunel, P. (2011). EFFECTS OF EXERCISE ON BRACHIAL SYSTOLIC BLOOD PRESSURE VERSUS CENTRAL AORTIC SYSTOLIC PRESSURE IN PATIENTS WITH HYPERTENSION. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57 (14), E564.
  • Doughty, R. N., Whalley, G. A., Gamble, G. D., Walsh, H., Jerums, G., Jacklin, C., . . . Williams, B. (2011). Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy. Journal of Hypertension, 29 (7), 1439-1447. doi:10.1097/HJH.0b013e3283480fe9
  • Krause, T., Lovibond, K., Caulfield, M., McCormack, T., Williams, B., & Grp, G. D. (2011). GUIDELINES Management of hypertension: summary of NICE guidance. BRITISH MEDICAL JOURNAL, 343, ARTN d4891. doi:10.1136/bmj.d4891
  • Williams, B. (2011). High blood pressure in young people and premature death. BMJ, 342 (7795), 450. doi:10.1136/bmj.d1104
  • Williams, B. (2011). High blood pressure in young people and premature death Alternative strategies are needed to stratify risk and determine treatment thresholds. BRITISH MEDICAL JOURNAL, 342.
  • Krause, T., Lovibond, K., Caulfield, M., McCormack, T., & Williams, B. (2011). Management of hypertension: Summary of NICE guidance. BMJ (Online), 343 (7821). doi:10.1136/bmj.d4891
  • Williams, B., Lacy, P., Yan, P., Chua, N. H., Liang, C., & Ting, C. M. (2011). Reply. Journal of the American College of Cardiology, 58 (16), 1731-1732. doi:10.1016/j.jacc.2011.07.014
  • Mcmanus, R., Mant, J., Bray, E., Holder, R., Jones, M., Greenfield, S., . . . Hobbs, R. (2010). A RANDOMISED CONTROLLED TRIAL OF TELEMONITORING AND SELF MANAGEMENT IN THE CONTROL OF HYPERTENSION: TELEMONITORING AND SELF MANAGEMENT IN HYPERTENSION (TASMINH2). JOURNAL OF HYPERTENSION, 28, E233.
  • Jones, M., McManus, R. J., Hobbs, F. D. R., Mant, J., Williams, B., Bryan, S., . . . Virdee, S. (2010). A RANDOMISED CONTROLLED TRIAL OF TELEMONITORING AND SELF MANAGEMENT IN THE CONTROL OF HYPERTENSION: TELEMONITORING AND SELF MANAGEMENT IN HYPERTENSION (TASMINH2): QUALITATIVE STUDY. JOURNAL OF HYPERTENSION, 28, E254.
  • Williams, B., Baschiera, F., Lacy, P. S., Botha, J., & Brunel, P. (2010). ATTENUATION OF EXERCISE-INDUCED RISE IN SYSTOLIC BLOOD PRESSURE BY THE DIRECT RENIN INHIBITOR ALISKIREN. JOURNAL OF HYPERTENSION, 28, E388.
  • Williams, B. (2010). BLOOD PRESSURE AND BEYOND: CHOOSING THE OPTIMAL COMBINATION IS A SCIENCE, NOT AN ART. JOURNAL OF HYPERTENSION, 28, E603.
  • Williams, B., & Lacy, P. S. (2010). Central haemodynamics and clinical outcomes: Going beyond brachial blood pressure?. European Heart Journal, 31 (15), 1819-1822. doi:10.1093/eurheartj/ehq125
  • Ninomiya, T., Zoungas, S., Neal, B., Woodward, M., Patel, A., Perkovic, V., . . . Williams, B. (2010). Efficacy and safety of routine blood pressure lowering in older patients with diabetes: Results from the advance trial. Journal of Hypertension, 28 (6), 1141-1149. doi:10.1097/HJH.0b013e328338a89c
  • Webb, D. R., Khunti, K., Silverman, R., Gray, L. J., Srinivasan, B., Lacy, P. S., . . . Davies, M. J. (2010). Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity. Diabetologia, 53 (6), 1190-1198. doi:10.1007/s00125-010-1689-9
  • Davies, J. E., Tillin, T., Malaweera, A., Lacy, P. S., Cruickshank, K., Stanton, A., . . . Hughes, A. D. (2010). Pressure-Independent Pulsatility Index (PIPI) Independently Predicts Cardiovascular Events in the Cafe Sub-Study of Ascot. CIRCULATION, 122 (21).
  • Kaambwa, B., Bryan, S., Mant, J., Bray, E. P., Holder, R., Jones, M., . . . Mcmanus, R. J. (2010). RANDOMISED CONTROLLED TRIAL OF TELEMONITORING AND SELF MANAGEMENT IN THE CONTROL OF HYPERTENSION: TELEMONITORING AND SELF MANAGEMENT IN HYPERTENSION (TASMINH2): ECONOMIC ANALYSIS. JOURNAL OF HYPERTENSION, 28, E281-E282.
  • McManus, R. J., Bray, E. P., Holder, R., Jones, M. I., Greenfield, S., Kaambwa, B., . . . Williams, B. (2010). Telemonitoring and self-management in the control of hypertension (TASMINH2): A randomised controlled trial. The Lancet, 376 (9736), 163-172. doi:10.1016/S0140-6736(10)60964-6
  • Chapman, N., Chen, C. -. Y., Fujita, T., Hobbs, F. R., Kim, S. -. J., Staessen, J. A., . . . Williams, B. (2010). Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?. Journal of Hypertension, 28 (9), 1796-1803. doi:10.1097/HJH.0b013e32833b912c
  • Ninomiya, T., Perkovic, V., De Galan, B. E., Zoungas, S., Pillai, A., Jardine, M., . . . Mancia, G. (2009). Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes. Journal of the American Society of Nephrology, 20 (8), 1813-1821. doi:10.1681/ASN.2008121270
  • Williams, B., Lacourcière, Y., Schumacher, H., Gosse, P., & Neutel, J. M. (2009). Antihypertensive efficacy of telmisartan vs ramipril over the 24-h dosing period, including the critical early morning hours: a pooled analysis of the PRISMA I and II randomized trials. J Hum Hypertens, 23 (9), 610-619. doi:10.1038/jhh.2009.4
  • Williams, B., Lacy, P. S., & Stanley, A. G. (2009). Blood pressure lowering efficacy of direct renin inhibition (aliskiren) in resistant hypertension - an observational study from UK primary care. JOURNAL OF HUMAN HYPERTENSION, 23 (10), 696.
  • Kengne, A. -. P., Czernichow, S., Huxley, R., Woodward, M., Neal, B., Zoungas, S., . . . Williams, B. (2009). Blood pressure variables and cardiovascular risk: New findings from advance. Hypertension, 54 (2), 399-404. doi:10.1161/HYPERTENSIONAHA.109.133041
  • Williams, B., & Lacy, P. S. (2009). Central aortic pressure and clinical outcomes. Journal of Hypertension, 27 (6), 1123-1125. doi:10.1097/HJH.0b013e32832b6566
  • Williams, B. (2009). Hypertension and the "J-curve". J Am Coll Cardiol, 54 (20), 1835-1836. doi:10.1016/j.jacc.2009.06.043
  • Williams, B., Lacy, P. S., & CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators. (2009). Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J Am Coll Cardiol, 54 (8), 705-713. doi:10.1016/j.jacc.2009.02.088
  • Williams, B., Lacy, P. S., Cruickshank, J. K., Collier, D., Hughes, A. D., Stanton, A., . . . CAFE and ASCOT Investigators. (2009). Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study. Circulation, 119 (1), 53-61. doi:10.1161/CIRCULATIONAHA.108.785915
  • De Galan, B. E., Perkovic, V., Ninomiya, T., Pillai, A., Patel, A., Cass, A., . . . Grobbee, D. E. (2009). Lowering blood pressure reduces renal events in type 2 diabetes. Journal of the American Society of Nephrology, 20 (4), 883-892. doi:10.1681/ASN.2008070667
  • Sleight, P., Redon, J., Verdecchia, P., Mancia, G., Gao, P., Pogue, J., . . . Williams, B. (2009). Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study. Journal of Hypertension, 27 (7), 1360-1369. doi:10.1097/HJH.0b013e32832d7370
  • McManus, R. J., Bray, E. P., Holder, R., Greenfield, S., Jones, M. I., Richard, F. D. R., . . . Williams, B. (2009). Protocol for a randomised controlled trial of telemonitoring and self-management in the control of hypertension: Telemonitoring and self-management in hypertension. [ISRCTN17585681]. BMC Cardiovascular Disorders, 9. doi:10.1186/1471-2261-9-6
  • Williams, B. (2009). Resistant hypertension: an unmet treatment need. Lancet, 374 (9699), 1396-1398. doi:10.1016/S0140-6736(09)61600-7
  • Redon, J., Sleight, P., Mancia, G., Gao, P., Verdecchia, P., Fagard, R., . . . Yusuf, S. (2009). SAFETY AND EFFICACY OF AGGRESSIVE BLOOD PRESSURE LOWERING AMONG PATIENTS WITH DIABETES: SUBGROUP ANALYSES FROM THE ONTARGET TRIAL. JOURNAL OF HYPERTENSION, 27, S16.
  • Williams, B. (2009). The Aorta and Resistant Hypertension. Journal of the American College of Cardiology, 53 (5), 452-454. doi:10.1016/j.jacc.2008.10.027
  • Williams, B. (2009). The changing face of hypertension treatment: Treatment strategies from the 2007 ESH/ESC hypertension Guidelines. Journal of Hypertension, 27 (SUPPL. 3). doi:10.1097/01.hjh.0000356768.24507.69
  • Williams, B. (2009). The changing face of hypertension treatment: treatment strategies from the 2007 ESH/ESC hypertension Guidelines. J Hypertens Suppl, 27 (3), S19-S26. doi:10.1097/01.hjh.0000356768.24507.69
  • Zoungas, S., Ninomiya, T., Patel, A., Perkovic, V., Woodward, M., Grobbee, D., . . . Chalmers, J. (2009). THE EFFECTS OF A FIXED COMBINATION OF PERINDOPRIL AND INDAPAMIDE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO BASELINE CARDIOVASCULAR RISK IN THE ADVANCE TRIAL. JOURNAL OF HYPERTENSION, 27, S314.
  • Williams, B. (2009). The year in hypertension. J Am Coll Cardiol, 55 (1), 65-73. doi:10.1016/j.jacc.2009.08.037
  • Williams, B. (2008). Achieving blood pressure control in clinical practice. Journal of the American Society of Hypertension, 2 (4 SUPPL.). doi:10.1016/j.jash.2008.03.009
  • Williams, B. (2008). Achieving blood pressure control in clinical practice. J Am Soc Hypertens, 2 (4 Suppl), S10-S15. doi:10.1016/j.jash.2008.03.009
  • Wilson, W. R. W., Herbert, K. E., Mistry, Y., Stevens, S. E., Patel, H. R., Hastings, R. A., . . . Williams, B. (2008). Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. EUROPEAN HEART JOURNAL, 29 (21), 2689-2694. doi:10.1093/eurheartj/ehn386
  • Sleight, P., Williams, B., Verdecchia, P., Gao, P., Redon, J., Mancia, G., . . . Yusuf, S. (2008). Blood pressure analyses from 25 595 patients (from 25 620 randomised) during the ONTARGET trial: reflections on current guidelines. JOURNAL OF HUMAN HYPERTENSION, 22 (10), 728.
  • Bakris, G., Böhm, M., Dagenais, G., Diener, H. -. C., Fujita, T., Gorelick, P., . . . Zannad, F. (2008). Cardiovascular protection for all individuals at high risk: Evidence-based best practice. Clinical Research in Cardiology, 97 (10), 713-725. doi:10.1007/s00392-008-0713-2
  • Lacy, P. S., & Williams, B. (2008). Impact of heart rate on the differential impact of blood pressure lowering drugs on central and peripheral pressures: Data from the Conduit Artery Function Evaluation (CAFE) study. JOURNAL OF HYPERTENSION, 26, S459.
  • Patel, A., MacMahon, S., Chalmers, J., Neal, B., Billot, L., Woodward, M., . . . De Galan, B. E. (2008). Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. New England Journal of Medicine, 358 (24), 2560-2572. doi:10.1056/NEJMoa0802987
  • Neutel, J. M., Schumacher, H., Gosse, P., Lacourcière, Y., & Williams, B. (2008). Magnitude of the early morning blood pressure surge in untreated hypertensive patients: A pooled analysis. International Journal of Clinical Practice, 62 (11), 1654-1663. doi:10.1111/j.1742-1241.2008.01892.x
  • Volpe, M., Erhardt, L. R. W., & Williams, B. (2008). Managing cardiovascular risk: The need for change. Journal of Human Hypertension, 22 (2), 154-157. doi:10.1038/sj.jhh.1002273
  • Williams, B., Lindholm, L. H., & Sever, P. (2008). Systolic pressure is all that matters. Lancet, 371 (9631), 2219-2221. doi:10.1016/S0140-6736(08)60804-1
  • Williams, B. (2008). The Hypertension in Diabetes Study (HDS): a catalyst for change. Diabet Med, 25 Suppl 2, 13-19. doi:10.1111/j.1464-5491.2008.02506.x
  • Williams, B. (2008). The year in hypertension. J Am Coll Cardiol, 51 (18), 1803-1817. doi:10.1016/j.jacc.2008.03.010
  • Williams, B. (2007). beta-blockers and the treatment of hypertension. JOURNAL OF HYPERTENSION, 25 (7), 1351-1353. doi:10.1097/HJH.0b013e328182266a
  • Williams, B. (2007). Central blood pressure lowering: Implications for clinical outcomes. JOURNAL OF HYPERTENSION, 25, S386.
  • Agabiti-Rosei, E., Mancia, G., O'Rourke, M. F., Roman, M. J., Safar, M. E., Smulyan, H., . . . Vlachopoulos, C. (2007). Central blood pressure measurements and antihypertensive therapy: A consensus document. Hypertension, 50 (1), 154-160. doi:10.1161/HYPERTENSIONAHA.107.090068
  • Rodger, R. S. C., & Williams, B. (2007). Consensus conference on early chronic kidney disease - Foreword. NEPHROLOGY DIALYSIS TRANSPLANTATION, 22, 1. doi:10.1093/ndt/gfm439
  • Lacy, P., Cruickshank, K., Thom, S., Stanton, A., Collier, D., & Williams, B. (2007). Diabetes accentuates the differential impact of blood pressure lowering drugs on central aortic pressure: Principal results from cafe-diabetes; The diabetic cohort within the conduit artery functional evaluation (CAFE) study. JOURNAL OF HYPERTENSION, 25, S279-S280.
  • Patel, A., MacMahon, S., Chalmers, J., Neal, B., Woodward, M., Billot, L., . . . Williams, B. (2007). Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet (London, England), 370 (9590), 829-840. doi:10.1016/s0140-6736(07)61303-8
  • Puig, J. G., Marre, M., Kokot, F., Fernandez, M., Jermendy, G., Opie, L., . . . Asmar, R. (2007). Efficacy of Indapamide SR Compared With Enalapril in Elderly Hypertensive Patients With Type 2 Diabetes. American Journal of Hypertension, 20 (1), 90-97. doi:10.1016/j.amjhyper.2006.05.018
  • Messerli, F. H., Williams, B., & Ritz, E. (2007). Essential hypertension. Lancet, 370 (9587), 591-603. doi:10.1016/S0140-6736(07)61299-9
  • Williams, B. (2007). Hypertension in the young - Preventing the evolution of disease versus prevention of clinical events. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 50 (9), 840-842. doi:10.1016/j.jacc.2007.05.020
  • Williams, B. (2007). Hypertension in the Young. Preventing the Evolution of Disease Versus Prevention of Clinical Events*Editorials published in the Journal of American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology. Journal of the American College of Cardiology, 50 (9), 840-842. doi:10.1016/j.jacc.2007.05.020
  • Williams, B., & Lacy, P. S. (2007). Impact of heart rate on the differential effect of blood pressure lowering agents on peripheral and central pressures: data from the Conduit Artery Function Evaluation (CAFE) Study. JOURNAL OF HUMAN HYPERTENSION, 21 (10), 836.
  • Higgins, B., & Williams, B. (2007). Pharmacological management of hypertension. Clinical Medicine, Journal of the Royal College of Physicians of London, 7 (6), 612-616.
  • Gosse, P., Neutel, J. M., Davidai, G., Schumacher, H., Lacourcière, Y., & Williams, B. (2007). The effect of telmisartan and ramipril on early morning blood pressure surge: A pooled analysis of two randomized clinical trials. Blood Pressure Monitoring, 12 (3), 141-147. doi:10.1097/MBP.0b013e3280b10bbd
  • Williams, B. (2007). The obese hypertensive: The weight of evidence against β-blockers. Circulation, 115 (15), 1973-1974. doi:10.1161/CIRCULATIONAHA.107.692970
  • Archibald, G., Bartlett, W., Brown, A., Christie, B., Elliott, A., Griffith, K., . . . Williams, B. (2007). UK consensus conference on early chronic kidney disease - 6 and 7 February 2007. Nephrology Dialysis Transplantation, 22 (9), 2455-2457. doi:10.1093/ndt/gfm268
  • Williams, B. (2007). β-blockers and the treatment of hypertension. Journal of Hypertension, 25 (7), 1351-1353. doi:10.1097/HJH.0b013e328182266a
  • Williams, B., Lacy, P. S., Thom, S. M., Cruickshank, K., Stanton, A., Collier, D., . . . CAFE Steering Committee and Writing Committee. (2006). Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation, 113 (9), 1213-1225. doi:10.1161/CIRCULATIONAHA.105.595496
  • Gosse, R., Schumacher, H., Lacourciere, Y., Neutel, J., & Williams, B. (2006). Effect of patient characteristics on the magnitude of the early morning blood pressure surge. JOURNAL OF HYPERTENSION, 24, S301.
  • Williams, B. (2006). Evolution of hypertensive disease: a revolution in guidelines. Lancet, 368 (9529), 6-8. doi:10.1016/S0140-6736(06)68943-5
  • Williams, B. (2006). Hypertension guidelines in the UK: A time for change. British Journal of Cardiology, 13 (4), 233-237.
  • Williams, B. (2006). Implications and controversies of recent hypertension trials - Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 48 (4), 849-850. doi:10.1016/j.jacc.2006.05.035
  • Dickinson, H. O., Mason, J. M., Nicolson, D. J., Beyer, F. R., Williams, B., & Ford, G. A. (2006). Lifestyle interventions to reduce raised blood pressure - Reply. JOURNAL OF HYPERTENSION, 24 (10), 2116-2117. doi:10.1097/01.hjh.0000244965.23351.71
  • Dickinson, H. O., Mason, J. M., Nicolson, D. J., Campbell, F., Beyer, F. R., Cook, J. V., . . . Ford, G. A. (2006). Lifestyle interventions to reduce raised blood pressure: A systematic review of randomized controlled trials. Journal of Hypertension, 24 (2), 215-223. doi:10.1097/01.hjh.0000199800.72563.26
  • Lacy, P., Carr, S. J., O'Brien, D., Fentum, B., Williams, B., Paul, S. K., & Robinson, T. G. (2006). Reduced glomerular filtration rate in pre-dialysis non-diabetic chronic kidney disease patients is associated with impaired baroreceptor sensitivity and reduced vascular compliance. Clin Sci (Lond), 110 (1), 101-108. doi:10.1042/CS20050192
  • Dickinson, H. O., Beyer, F. R., Mason, J. M., Nicolson, D. J., Williams, B., & Ford, G. A. (2006). Reply [3]. Journal of Hypertension, 24 (10), 2116-2117. doi:10.1097/01.hjh.0000244965.23351.71
  • Williams, B., Lacy, P. S., Thurston, H., Thom, S., Hughes, A., Cruickshank, K., . . . O'Rourke, M. (2006). Response to letters regarding article, "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) Study" [5]. Circulation, 114 (15). doi:10.1161/CIRCULATIONAHA.106.640870
  • Williams, B., Gosse, P., Lowe, L., Harper, R., & PRISMA I Study Group. (2006). The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMA I). J Hypertens, 24 (1), 193-200.
  • Williams, B. (2006). The year in hypertension. J Am Coll Cardiol, 48 (8), 1698-1711. doi:10.1016/j.jacc.2006.06.074
  • Stanley, A. G., Swales, P., Thurston, H., & Williams, B. (2006). Treating resistant hypertension in type 2 diabetes: A role for spironolactone?. British Journal of Diabetes and Vascular Disease, 6 (2), 90-92. doi:10.1177/14746514060060020701
  • Williams, B. (2005). ASCOT - Hold on to your horses!. British Journal of Cardiology, 12 (5), 336-338.
  • Williams, B., & Lacy, P. S. (2005). Blood pressure and outcomes in clinical trials. J Hypertens, 23 (3), 487-488.
  • WILLIAMS, B. (2005). Hypertension in Diabetes - Clinical Science to Clinical Practice. 日本内分泌学会雑誌, 81 (1).
  • Lacy, P., & Williams, B. (2005). Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes - Reply. JOURNAL OF HYPERTENSION, 23 (3), 670-671. doi:10.1097/01.hjh.0000160230.32339.a5
  • Khoshdel, A. R., Carney, S. L., Lacy, P., & Williams, B. (2005). Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes [3] (multiple letters). Journal of Hypertension, 23 (3), 669-671.
  • Neutel, J. M., Gosse, P., Schumacher, H., Williams, B., & Lacourciere, Y. (2005). Magnitude of the early morning blood pressure surge in hypertensive patients. AMERICAN JOURNAL OF HYPERTENSION, 18 (5), 39A-40A. doi:10.1016/j.amjhyper.2005.03.107
  • Neutel, J., Gosse, P., Schumacher, H., Williams, B., & Lacourciere, Y. (2005). Magnitude of the early morning blood pressure surge in hypertensive patients. JOURNAL OF HYPERTENSION, 23, S374.
  • Williams, B. (2005). Recent hypertension trials: implications and controversies. J Am Coll Cardiol, 45 (6), 813-827. doi:10.1016/j.jacc.2004.10.069
  • Gosse, P., Neutel, J. M., Schumacher, H., Lacourciere, Y., & Williams, B. (2005). Reduction of early morning blood pressure surge with telmisartan compared with ramipril in mild-to-moderate hypertensive patients. AMERICAN JOURNAL OF HYPERTENSION, 18 (5), 60A. doi:10.1016/j.amjhyper.2005.03.164
  • Gosse, P., Neutel, J., Schumacher, H., Laccourciere, Y., & Williams, B. (2005). Reduction of early morning blood pressure surge with telmisartan compared with ramipril in mild-to-moderate hypertensive patients. JOURNAL OF HYPERTENSION, 23, S375-S376.
  • Williams, B., Lacourciere, Y., Schumacher, H., Gosse, P., & Neutel, J. M. (2005). Telmisartan versus ramipril in 24-h ambulatory blood pressure: A pooled analysis of 2 prospective, randomized trials in mild-to-moderate hypertensive patients. AMERICAN JOURNAL OF HYPERTENSION, 18 (5), 76A. doi:10.1016/j.amjhyper.2005.03.209
  • Williams, B., Lacourciere, Y., Schumacher, H., Gosse, P., & Neutel, J. (2005). Telmisartan versus ramipril in 24-H ambulatory blood pressure: A pooled analysis of 2 prospective, randomized trials in mild-to-moderate hypertensive patients. JOURNAL OF HYPERTENSION, 23, S380.
  • Mason, J. M., Dickinson, H. O., Campbell, F., Ford, G. A., Nicolson, D. J., & Williams, B. (2005). The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension. Journal of Hypertension, 23 (10), 1777-1781.
  • Williams, B., Poulter, N. R., Brown, M. J., Davis, M., McInnes, G. T., Potter, J. F., . . . BHS guidelines working party, for the British Hypertension Society. (2004). British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ, 328 (7440), 634-640. doi:10.1136/bmj.328.7440.634
  • Marre, M., Puig, J. G., Kokot, F., Fernandez, M., Jermendy, G., Opie, L., . . . Asmar, R. (2004). Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: The NESTOR study. Journal of Hypertension, 22 (8), 1613-1622. doi:10.1097/01.hjh.0000133733.32125.09
  • Williams, B., Poulter, N. R., Brown, M. J., Davis, M., McInnes, G. T., Potter, J. F., . . . British Hypertension Society. (2004). Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens, 18 (3), 139-185. doi:10.1038/sj.jhh.1001683
  • Williams, B. (2004). Guidelines from the British Hypertension Society - Numbers are missing - Reply. BRITISH MEDICAL JOURNAL, 329 (7465), 570-571. doi:10.1136/bmj.329.7465.570-b
  • Burns, G. E., Green, P. N., Duerden, M. G., Sackin, P. A., Davies, P., & Williams, B. (2004). Guidelines from the British Hypertension Society [1] (multiple letters). British Medical Journal, 329 (7465), 569-571.
  • Lacy, P. S., O'Brien, D. G., Stanley, A. G., Dewar, M. M., Swales, P. P., & Williams, B. (2004). Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes. J Hypertens, 22 (10), 1937-1944.
  • Williams, B. (2004). Protection against stroke and dementia: an update on the latest clinical trial evidence. Curr Hypertens Rep, 6 (4), 307-313.
  • Williams, B. (2004). Pulse wave analysis and hypertension: Evangelism versus scepticism. Journal of Hypertension, 22 (3), 447-449. doi:10.1097/00004872-200403000-00002
  • Hastings, R., Li, N. C., Lacy, P. S., Patel, H., Herbert, K. E., Stanley, A. G., & Williams, B. (2004). Rapid telomere attrition in cardiac tissue of the ageing Wistar rat. Exp Gerontol, 39 (5), 855-857. doi:10.1016/j.exger.2004.02.003
  • Williams, B., Wilson, K., Lacey, L., Marchant, N., & Lister, S. (2004). The prevalence and management of patients with co-existing hypertension and hypercholesterolaemia in the UK. EUROPEAN HEART JOURNAL, 25, 528-529.
  • Williams, B. (2004). VALUE and supremacy of blood pressure control for cardiovascular protection. Journal of Hypertension, 22 (8), 1435-1437. doi:10.1097/01.hjh.0000133749.15985.de
  • Lasaridis, A. N., Sarafidis, P. A., Williams, B., Julius, S., & McInnes, G. T. (2004). What lies behind the intense criticism of ALLHAT? (multiple letters). Journal of Hypertension, 22 (1), 223-227. doi:10.1097/00004872-200401000-00033
  • Williams, B., & Poulter, N. (2004). What's new in the new British Hypertension Society guidelines for the management of hypertension - BHS IV. British Journal of Cardiology, 11 (2), 112-117.
  • Mancia, G., Rosei, E. A., Cifkova, R., DeBacker, G., Erdine, S., Fagard, R., . . . Cardiology, E. S. (2003). 2003 European society of hypertension - European Society of Cardiology guidelines for the management of arterial hypertension. JOURNAL OF HYPERTENSION, 21 (6), 1011-1053. doi:10.1097/01.hjh.0000059051.65882.32
  • Brown, M. J., Cruickshank, J. K., Dominiczak, A. F., MacGregor, G. A., Poulter, N. R., Thom, S., . . . Williams, B. (2003). Better blood pressure control: How to combine drugs. Journal of Human Hypertension, 17 (2), 81-86. doi:10.1038/sj.jhh.1001511
  • Williams, B. (2003). Drug specific benefits and cardiovascular and stroke outcomes. Journal of Hypertension, 21 (9), 1609-1610. doi:10.1097/00004872-200309000-00002
  • Williams, B. (2003). Drug treatment of hypertension. British Medical Journal, 326 (7380), 61-62.
  • Williams, B. (2003). Drug treatment of hypertension - Most patients will need a treatment cocktail-including a thiazide diuretic. BRITISH MEDICAL JOURNAL, 326 (7380), 61-62. doi:10.1136/bmj.326.7380.61
  • Williams, B. (2003). Drug treatment of hypertension - The future is combination therapy. British Journal of Cardiology, 10 (SUPPL. 3).
  • Williams, B. (2003). Drug treatment of hypertension: Implications of ALLHAT. Heart, 89 (6), 589-590.
  • Marre, M., Chastang, C., Ollivier, J. -. P., Asmar, R., Amouyel, P., Puig, J. G., . . . Pozza, G. (2003). Effect of indapamide SR on microalbuminuria - The NESTOR study (Natrilix SR versus Enalapril Study in Type 2 diabetic hypertensives with micrOalbuminuRia) - Rationale and protocol for the main trial. Journal of Hypertension, Supplement, 21 (1).
  • Williams, B. (2003). Treating hypertension: It is not how you start but where you end that matters. Journal of Hypertension, 21 (3), 455-457. doi:10.1097/00004872-200303000-00002
  • Williams, B. (2003). Treatment of hypertension in the UK: Simple as ABCD?. Journal of the Royal Society of Medicine, 96 (11), 521-522. doi:10.1258/jrsm.96.11.521
  • Stanley, A. G., O'Brien, D. G., Lacy, P. L., Shiels, A., Thurston, H., & Williams, B. (2002). A novel correction factor for ambulatory blood pressure monitoring in hypertensive subjects. JOURNAL OF HYPERTENSION, 20, S238.
  • Williams, B. (2002). Angiotensin II receptor antagonism in diabetic education nephropathy: Commentary. Diabetic Medicine, 19 (SUPPL. 3), 10-11.
  • Swales, P., & Williams, B. (2002). Calcium channel blockade in combination with angiotensin-converting enzyme inhibition or angiotensin II (AT(1)-receptor) antagonism in hypertensive diabetics and patients with renal disease and hypertension. J Renin Angiotensin Aldosterone Syst, 3 (2), 79-89. doi:10.3317/jraas.2002.022
  • Redon, J., & Williams, B. (2002). Microalbuminuria in essential hypertension: redefining the threshold. JOURNAL OF HYPERTENSION, 20 (3), 353-355. doi:10.1097/00004872-200203000-00002
  • Lacy, P. S., O'Brien, D. G., Stanley, A. G., Swales, P. P. R., Carr, S. J., & Williams, B. (2002). Radial artery pulse wave analysis fails to demonstrate increased vascular stiffness in diabetic patients. JOURNAL OF HYPERTENSION, 20, S256.
  • Bates, D. O., Hillman, N. J., Williams, B., Neal, C. R., & Pocock, T. M. (2002). Regulation of microvascular permeability by vascular endothelial growth factors. JOURNAL OF ANATOMY, 200 (6), 581-597. doi:10.1046/j.1469-7580.2002.00066.x
  • O'Callaghan, C. J., & Williams, B. (2002). The regulation of human vascular smooth muscle extracellular matrix protein production by α- and β- adrenoceptor stimulation. Journal of Hypertension, 20 (2), 287-294. doi:10.1097/00004872-200202000-00019
  • Williams, B. (2001). Angiotensin II and the pathophysiology of cardiovascular remodeling. American Journal of Cardiology, 87 (8 SUPPL.).
  • Williams, B. (2001). Angiotensin II and the pathophysiology of cardiovascular remodeling. Am J Cardiol, 87 (8A), 10C-17C.
  • Poulter, N., & Williams, B. (2001). Doxazosin for the management of hypertension: Implications of the findings of the ALLHAT Trial. American Journal of Hypertension, 14 (11 I), 1170-1172. doi:10.1016/S0895-7061(01)02212-9
  • Poulter, N., & Williams, B. (2001). Doxazosin for the management of hypertension: Implications of the findings of the ALLHAT Trial. AMERICAN JOURNAL OF HYPERTENSION, 14 (11), 1170-1171. doi:10.1016/S0895-7061(01)02212-9
  • Spratt, J. C. S., Webb, D. J., Shiels, A., & Williams, B. (2001). Effects of candesartan on cardiac and arterial structure and function in hypertensive subjects. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 2 (4), 227-232.
  • Williams, B., O'Rourke, M., & Anglo-Scandinavian Cardiac Outcomes Trial. (2001). The Conduit Artery Functional Endpoint (CAFE) study in ASCOT. J Hum Hypertens, 15 Suppl 1, S69-S73.
  • Cappuccio, F. P., Conlon, C. P., John, C. S., Dornhurst, A., Douglas, J. G., Elborn, J. S., . . . Thurston, H. (2001). The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 2001. QJM - Monthly Journal of the Association of Physicians, 94 (11), 643-655.